Synthesis, Anti-Hiv activity and Cytotoxicity of 2-Phenyl, 3-Sulphonamido Quinazolin-4 (3h) -ones
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2012, Vol 1, Issue 1
Abstract
A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo [1,3] oxazine-4-ones and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR and 1H-NMR). Synthesized compounds were screened for in vitro antiviral activity against HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the synthesized compounds exhibited cytotoxicity in MT-4 cells (CC50: 1.93-87 μg/ml) and compound SPB-III displayed marked cytostatic properties in MT-4 cells (CC50:1.93± 0.29μg/ ml).
Authors and Affiliations
Selvam P
Keywords
Related Articles
- EP ID EP648895
- DOI -
- Views 53
- Downloads 0
RP-HPLC method development and validation of doxycycline in bulk and tablet formulation
A Simple, accurate and rapid RP-HPLC method has been developed for the estimation of doxycycline (DOXY) in bulk and pharmaceutical dosage forms using an Altima C 18, 150 x 4.6 mm i.d, 5 µm particle size in isocratic mode...
Analytical method development and validation for residual solvent of Diltiazem hydrochloride extended release capsule by Gas chromatography
Residual solvents are organic volatile chemicals that are either used or produced during the manufacture of active pharmaceutical ingredients, excipients, and drug products. Organic solvents such as di ethyl ether, N hep...
Spectral analysis of whole plant ethanol extract of Blepharisrepens (vahl) roth and its fraction
The whole plant of Blepharisrepens (vahl) Roth, have a great medicinal value. The aim of the present study was to determine the chemical profile of ethanolic extract of Blepharisrepens (vahl) Rothand its fractions (by va...
Formulation and evaluation of matrix type rosuvastatin sustained release tablets
Sustained release tablets of Rosuvastatin were developed to prolong release of time leading to an increase in drug bioavailability.Tablets are prepared by direct compression technique using polymers HPMC K15M,HPMC K50M a...
Synthesis and screening of new 2-(2-oxoindoline-3-ylidene)-n- Phenyl hydrazine carbothioamides
The purpose of this work to prepare or to synthesize the little compound, 2-(2-oxoindoline-3-ylidene)-N-phenyl hydrazine carbothioamide derivatives by adopting appropriate synthetic routes. Then Purification and characte...