Synthesis, Anti-HIV activity and Cytotoxicity of N-Substituted Phthalimide derivatives
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2013, Vol 2, Issue 1
Abstract
A series of novel N-substituted phthalimide derivatives have been synthesized by condensation of phthalic anhydride and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR and 1H-NMR). Synthesized compounds were screened for antiviral activity against HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells. All the synthesized compounds exhibited cytotoxicity in MT-4 cells (CC50: 84-125 μg/ml).
Authors and Affiliations
Selvam P
Keywords
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