Synthesis, Anti-Inflammatory and Antimicrobial Evaluation of Novel 2-phenyl-3-((4-phenylthiazol-2-yl) amino)thiazolidin-4- One Derivatives
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2023, Vol 7, Issue 3
Abstract
n order to explore the therapeutic potential of thiazolidinone based analogues, five novel 2-phenyl-3-((4-phenylthiazol-2-yl) amino)thiazolidin-4-one derivatives (7a-e) were synthesized using multistep synthetic methodology. Structural elucidation of all synthesized molecules was performed by using IR and 1H NMR spectral reports. All molecules were accessed for their anti-microbial potential against a panel of four bacterial strains and one fungal strain. Results of in vitro antimicrobial data revealed compounds 7c and 7d as most potent antibacterial agent towards E. coli, S. aureus and B. subtilis with MIC values of 6.25 µg/mL while Compounds 7a, 7b and 7e as most active antifungal agents against tested fungal species i.e., R. oryaze (MIC = 3.125 µg/mL). Further, in vitro anti-inflammatory potential was evaluated for synthesized molecules in which compound 7d have powerful anti-inflammatory profile with IC50 value of 1.27 µg/Ml.
Authors and Affiliations
Mudgil S, Kumar M, Lamba P, Nehra B* and Rani P
Keywords
Related Articles
- EP ID EP751858
- DOI 10.23880/oajpr-16000287
- Views 1
- Downloads 0
Impact of Consciousness Energy Healing Treatment on the Isotopic Abundance Ratio of Cefazolin Sodium Using LC-MS and GC-MS Spectrometry
Cefazolin sodium is a broad-spectrum antibiotic useful for the treatment of many Gram-positive and some Gram-negative bacterial infections. This study was designed to investigate the impact of The Trivedi Effect®-Biofie...
Virtual Screening and Validation of Potential Lead Compound from the Malaria Box against Plasmodium Falciparum S7 and S19 Proteins
Molecular docking is a computer based tool used in drug design, where predominant binding modes of a ligand with known three dimensional protein structures are predicted. This study addresses the possible ways of coming...
Lercanidipine Over Other Calcium Channel Blocker in Elderly Patients & its Renal Protection in Future
A calcium channel blocker called lercanidipine shows promise as a treatment for hypertension, especially in older people. Exhibiting greater effectiveness in comparison to other calcium channel blockers, it presents enc...
Synthesis, Anti-Inflammatory and Antimicrobial Evaluation of Novel 2-phenyl-3-((4-phenylthiazol-2-yl) amino)thiazolidin-4- One Derivatives
n order to explore the therapeutic potential of thiazolidinone based analogues, five novel 2-phenyl-3-((4-phenylthiazol-2-yl) amino)thiazolidin-4-one derivatives (7a-e) were synthesized using multistep synthetic methodo...
Cytotoxic and Anti-Cervical Cancer Effects of the Camellia sinensis Byproducts from Various Kenyan Factories
Cervical cancer is a significant global health challenge and necessitates the search for innovative and patient-friendly therapies due to the limitations and challenges posed by conventional treatments. This study explo...