SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF 2-HYDROXY PHENYL THIAZOLIDINE-4-ONE DERIVATIVE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 8
Abstract
A new series of N-(2-(2-hydroxyphenyl)-4-oxothiazolidin-3-yl) isonicotinamide derivatives were synthesized by the reaction of schiff base (Isoniazid and 2 hydroxy benzaldehyde) with mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. The synthesized compounds showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
Authors and Affiliations
S. Ramachandran
Keywords
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