Synthesis, Characterization and Antimicrobial Evaluation of Co(II), Ni(II) and Cu(II) Schiff base complexes of (Z)-4-(1-pyridin-4-ylimino) propyl)phenol
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 9
Abstract
Received 15 August 2018 Revised 24 August 2018 Accepted 30 August 2018 Published online 21 September 2018 The demand for discovery and development of new antimicrobial agents has continued to increase due to the emergence and increasing prevalence of drug resistant pathogens. The study evaluated the synthesis, characterization and antimicrobial activity of Co(II), Ni(II) and Cu(II) Schiff base complexes derived from condensation of (Z)-4-(1-pyridin-4-ylimino) propyl) phenol with their respective metal chlorides. The synthesized Co(II), Ni(II) and Cu(II) Schiff base complexes were characterized by UV-Visible analysis, FTIR, Molar conductivity measurement and Magnetic susceptibility test. The results of the FTIR suggest that the metal complexes possess coordinated water molecules and the absorption band with wavenumber 1651.12 and 1658.84 cm-1 shows that the nitrogen of the imine bond participated in the coordination to the metal center. The magnetic susceptibility measurements show magnetic moments of 4.68 BM, 3.10 BM and 1.95 BM corresponding to Co (II), Ni (II) and Cu (II) complexes, respectively, thus, indicating the metal complexes possess octahedral geometry. The molar conductivity tests show values of 82.90 Ω1mol-1cm2, 62.60 Ω-1mol-1cm2 and 50.80 Ω-1mol-1cm2 which corresponds to Co(II), Ni(II) and Cu(II) complexes respectively. The molar conductivity values for the complexes show that they do not readily dissociate in solution and are non-electrolytic in nature. The metal to ligand ratio for each of the metal complexes is 1:2. The metal complexes were evaluated for their antimicrobial activity against two Gram positive bacteria, two Gram negative bacteria and two fungi organisms. The synthesized metal complexes show significant activities against most of the test organisms.
Authors and Affiliations
Samuel A. Agbese, Gideon A. Shallangwa, Sulaiman O. Idris
Keywords
Related Articles
- EP ID EP497743
- DOI 10.26538/tjnpr/v2i9.4
- Views 77
- Downloads 0
Phytochemical Analysis and Hypoglycaemic Activity of the Methanol Stem Bark Extract of Tabernaemontana pachysiphon Stapf (Apocynaceae)
Tabernaemontana pachysiphon Staph. (Apocynaceae) stem bark is used ethnomedicinally for the treatment of diabetes. This study determined the phytochemical constituents and evaluate the methanol stem bark extract for acut...
Bioassay-coupled Chromatographic Analysis of Medicinal Natural Products: A Review
Medicinal plants have found immense use in drug discovery over the years as several chemically available drugs today are either directly from plant secondary metabolites or have their templates from such. Recent advances...
Characterization and Evaluation of the Suspending Potentials of Corchorus olitorius Mucilage in Pharmaceutical Suspensions
The study was aimed at extraction, characterization and evaluation of suspending potentials of Corchorus olitorius mucilage (COM) in comparison with acacia BP (ACG) in pharmaceutical suspensions. Corchorus olitorius muci...
Medicinal Plants Used in the Treatment of Pregnancy Related Problems in Sokoto State, Nigeria
Received 31 October 2018 Revised 21 November 2018 Accepted 25 November 2018 Published online 27 November 2018 The use of plants during pregnancy is a common practice in Africa. In Nigeria, despite modern medical antenat...
Synthesis and Antimicrobial Evaluation of N,N’-(4-Nitro-1,2-phenylene)diamide Derivatives
Received 01 July 2018 Revised 18 July 2018 Accepted 23 July 2018 Published online 10 August 2018 In the search for new antibiotics, 4-nitro-1,2-phenylenediamide analogues were synthesized via nucleophilic addition/elimi...