Synthesis, Characterization and Blood Based Toxic Effects of Superparamagnetic Nanoparticles
Journal Title: Materials Science-Medžiagotyra - Year 2019, Vol 25, Issue 4
Abstract
The objective of this study is to the assess toxicity of superparamagnetic nanoparticles within normal and diabetic human blood groups using complete blood count (CBC). For this purpose, iron oxide nanoparticles (IONPs) were synthesized by co-precipitation method. Samples were characterized by XRD, SEM, EDS, VSM and CBC. XRD confirmed the cubic structure of Fe3O4 with Miller indices (2 0 0), (2 2 0), (3 1 1), (4 0 0), (4 4 0) and average size of magnetic nanoparticles was calculated about 11.13 nm diameter. The morphology of Fe3O4 nanoparticles was investigated by scanning electron microscope (SEM). SEM images of magnetite were found partially smooth. Spectra of EDX depicted the Fe, O and Cl elements in IONP. Magnetic properties were examined by vibrating sampling magnetometer (VSM). The blood toxicity was reported by blood contents in normal and diabetic blood samples for specified intervals using CBC technique. One sample test of variance of hemoglobin, erythrocytes, leucocytes and thrombocytes showed the significant difference (p > 0.05) among 0 hrs to 72 hrs for all normal and diabetic blood samples. This study concluded that presence of iron oxides nanoparticles of size 11.13 nm in human blood induces reactive oxygen species which cause the cell death. Hemoglobin was highly affected content of blood than erythrocytes, leucocytes by toxic effects of IONPs. Reduction of platelets among all content of blood groups posed another signature of this hematology study. Toxic spectrum of IONPs must be considered before the application of MRI contrast agents and drug delivery.
Authors and Affiliations
Muhammad Javid ARSHAD, Saddique AMIR, Mehmood ZAHID, Amin NIAMA, Husain FAYYAZ, Muhammad Anjum NAEEM, Saeed Ahmad BUZDAR, Muhammad IMRAN
Keywords
Related Articles
- EP ID EP674656
- DOI 10.5755/j01.ms.25.4.21149
- Views 57
- Downloads 0
Electrolytic Preparation of Al-Sm Alloy in SmF3-LiF-Sm2O3 Molten Salt System
In the present paper, an Al rod as liquid cathode was added into the SmF3-LiF-Sm2O3 molten salt system and subsequently the Al-Sm alloy was prepared by the liquid cathode electrolysis method. The effects of electrolysis...
Research on Tensile Behaviour of New Structural Material MoNiCa
This article presents the results of a set of innovative research to analyse a new structural material – steel like austempered ductile cast iron with mechanical properties similar to heat-treated steel, and with technol...
Applications of Field-Reversal and Angle-Dependent XMCD Techniques to Mn-Based Diluted Magnetic Materials
Recent progress of the soft X-ray magnetic circular dichroism (XMCD) techniques and relevant applications at beamline 4B7B in Beijing Synchrotron Radiation Facility are reported here. The key progress of the XMCD techniq...
Experimental Study on the Thermal Decomposition of Two Nitrocellulose Mixtures in Different Forms
In order to ensure the safety of nitrocellulose (NC) mixtures in storage, transportation and usage, it is necessary to study the thermal stability of NC mixtures. In the present study, the thermal decomposition of two co...
A Novel and Facile Method to Synthesize Self-Assembled BiOCl Core-shell Microspheres Composed of Nanoplates
The self-assembled BiOCl core-shell microspheres composed of nanoplates have been successfully prepared using solvothermal method using ethylene glycol and polyvinylpyrrolidone (PVP) as solvents. XRD, SEM, EDX, XPS and D...