Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2016, Vol 12, Issue 12
Abstract
Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by   FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation
Authors and Affiliations
dhinesh kumar manoharan
Keywords
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- EP ID EP652923
- DOI 10.24297/jac.v12i12.4826
- Views 146
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