Abstract

The novel heterocyclic compounds 6aH,13H-enz[4,5]oxazole[2,3,2,3][1,3]thiazino[6,5- b]quinolin-13-one derivatives 4-15 have been synthesized by conventional method. The various derivatives of 1,3-benzoxazole-2-thiol were on treating with 2-chloroquinoline-3- carbaldehyde derivatives in DMF yielded target novel molecules 4-15. The obtained products have been characterized by IR, 1H NMR, 13C NMR and Mass spectral studies. The newly synthesized compounds were screened for their in vitro cytotoxic, antibacterial and molecular docking studies. The synthesized compounds 9-Chloro-10-nitro-6aH,13Hbenz [4’,5’]oxazole [2’,3’,:2,3] [1,3]thiazino[6,5b]quinolin-13 one 6, 2,10-dichloro-6aH, 13H benz [4’,5’] oxazole [2’,3’,:2,3][1,3]thiazino[6,5-b]quinolin-13-one 9 and 2,8,10-Trichloro- 6aH,13Hbenz [4’,5’] oxazole[2’,3’,:2,3][1,3]thiazino[6,5-b]quinolin-13-one 15 exhibited potent cytotoxic activity towards Peripheral Blood Mononuclear Cells (PBMCs) with the influence of functional groups attached with central moiety. The cytotoxic results were further supported by molecular interaction by molecular docking studies with receptor PDB ID: 3FLY and showed a minimum binding energy and higher affinity towards the active pocket sites. The study also focused on screening of antibacterial activity and most of the compounds from the series exhibited considerable bacterial inhibition.

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