Development of a New Rapid, Efficient and Reproducible Reverse Phase - HPLC Method for the Analysis of Decitabine in Bulk and Tablet Dosage Form
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 4
Abstract
Development of a new rapid, efficient and reproducible reverse phase-HPLC method for the analysis of Decitabine in bulk drug and tablet dosage form. This separation was achieved by using Develosil ODS HG-5 RP column 150mm x 4.6mm, 5μm (particle size) i.d. in isocratic mode, with mobile phase containing ACN : Acetate buffer (55:45), adjusted to pH 3.9 using ortho phosphoric acid. The flow rate was maintained at 1.0 ml/min and analyte were monitored at 254 nm. The retention time of Decitabine was found to be 2.97 min. The linearity for Decitabine were in the range of 0-60 μg/ml. The recoveries of Decitabine were found in the range of 100.4933%, 101.4733% and 100.0467%. The developed method was validated as per ICH guidelines and successfully applied to the further analysis of Decitabine in bulk and tablet dosage form
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