SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL EVALUATION OF SOME NEW AMIDES OF THIOMORPHOLINE CARBOXYLATE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: Synthesis and antimicrobial evaluation of some new amides of Thiomorpholine caboxylate.Methods: A series of new amides of Thiomorpholine caboxylate were synthesized by reacting 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide with primary amines in presence of Trimethyl aluminum in toluene at ambient temperature in good yields. 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide was synthesized by reacting tert-butyl thiomorpholine-4-carboxylate 1,1-dioxide with methyl chloroformate in presence of LiHMDS (1M in THF) at -78oC for the first time. The newly synthesized compounds were characterized by IR, 1HNMR, 13C NMR, Mass spectral studies and elemental analysis.Results: A series of new amides of Thiomorpholine carboxylate were synthesized in good yields and all the compounds were screened for their In-vitro antimicrobial activities. Conclusion: Preliminary results revealed that the synthesized compounds were showed moderate to good antibacterial and antifungal activity.
Authors and Affiliations
Vasudeva Reddy Nagavelli, Kumaraswamy B, Ranjith Kumar T, Narsimha S
Keywords
Related Articles
- EP ID EP579610
- DOI -
- Views 55
- Downloads 0
OPTIMIZATION OF LIPASE PRODUCTION FROM DIFFERENT AGROINDUSTRIAL WASTES BY MARINE ACTINOMYCETES
Objective: To identify the production of extracellular lipase by solid state fermentation (SSF) using coconut cake and groundnut cake using thermophilic strain of marine actinomycetes.Methods: From the isolated strains o...
EFFICACY OF PHARMACOLOGICAL AGENTS IN THE TREATMENT OF TEMPOROMANDIBULAR JOINT DISORDER: A SYSTEMATIC REVIEW
The  aim of this article is to analyse the effectiveness of pharmacological agents for treatment of Wilke’s disease, anterior disc displacement without reduction, post arthroscopy TMJ pain, and internal disc derangeme...
DEVELOPMENT OF COLON-SPECIFIC MULTI PARTICULATE DRUG DELIVERY SYSTEM OF FENOVERINE
Objective: The main objective of this study was to formulate and evaluate colon-specific multi- particulate drug delivery system of fenoverine, using Eudragit S 100 as enteric coating polymer.Methods: Microparticles were...
POSTPARTUM HEALTH RELATED QUALITY OF LIFE AFTER DIFFERENT MODES OF DELIVERY AMONG WOMEN IN PAKISTAN: THE NEGLECTED LINK FOR BETTER MATERNAL and CHILD HEALTH
Objective: The present study was designed to evaluate women postpartum quality of life after different modes of delivery in Pakistan.Methods: A descriptive cross-sectional study design was used. A pre-validated tool SF-3...
CHARACTERISATION OF CAROTENOID CONTENT IN DIVERSE LOCAL SWEET POTATO (IPOMOEA BATATAS) FLESH TUBERS
Sweet potato (Ipomoea batatas) is one of the most important food crops in the world. Sweet potato is rich with carotenoids and pro-vitamin A. Carotenoids compounds are commonly found in fruits and vegetables and are res...