SYNTHESIS, CHARACTERIZATION AND OF NOVEL N-[2-CHLORO-4-(TRIFLUOROMETHYL) PHENYL]-2-OXO-4-(SUBSTITUTED PHENYL)-6-(PROPAN-2-YL)-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDE
Journal Title: Journal of Atoms and Molecules - Year 2012, Vol 2, Issue 5
Abstract
N-[2-chloro-4-(trifluoromethyl)phenyl]-2-oxo-4-(substitutedphenyl)-6-(propan-2-yl)-1,2,3,4- tetrahydropyrimidine-5-carboxamide (4a-o) are synthesized. The synthesis of (4a-o) was achieved by acid catalysed cyclocondensation of N-[2-chloro-4-(trifluoromethyl)phenyl]-4-methyl-3- oxopentanamide, urea and Benzaldehydes. The products were characterized by FT-IR, mass spectra, 1H NMR and elemental analyses. The newly synthesized compounds were subjected to various biological activities viz., antimicrobial.
Authors and Affiliations
Nitesh Chauhan, Kiran Nimavat, Kartik Vyas
Keywords
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