Synthesis, characterization and pharmacological evaluation of substituted 4-aryl thiazole-2-amino acetanilides
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2016, Vol 4, Issue 3
Abstract
A series of novel 4-aryl thiazole-2-amino acetanilides (B1-B6) was designed and synthesized via the preparation of 2-amino 4-aryl thiazole (1) by acetophenone and thiourea which on subsequent condensation with α-chloroacetanilides offered title compounds. The newly synthesized compounds were characterized by elemental analysis, IR and 1HNMR and Mass spectral data. The synthesized compounds were tested for their in-vitro antimicrobial activity against the four bacterial strains i.e., Bacillus subtilis, Streptococcus pneumonia, Escherichia coli & Staphylococcus aureus and two fungal strains i.e Aspergilus. Niger and Candida albicans using disk diffusion method. The synthesized derivatives demonstrated moderate to excellent growth inhibition of microbes. The compounds were also tested for their anti-inflammatory and analgesic potential using carageenan induced hind paw oedema and acetic acid induced writhing methods respectively. A promising activity was observed in some of the title compounds when compared to standard drug diclofenac sodium .
Authors and Affiliations
Priyanka| Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Bagarpur, Moradabad, India, Isha| Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Bagarpur, Moradabad, India, Keshari Kishore Jha| Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Bagarpur, Moradabad, India, M. Vijayakumar| Research Scientist, The Himalaya Drug Company, Makali, Bangalore, India
Keywords
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