Synthesis, characterization, electrochemical and antimicrobial properties of half-sandwich ruthenium(II) complexes containing substituted bipyridine ligands.
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 10
Abstract
Half-sandwich ruthenium complexes, [(η6 - C6H5CH3)RuCl(N,N]PF6 where (N,N) = 5,5-dimethyl2,2’-bipyridine ,4,4’-di-tert-butyl-2,2’-bipyridine and 2,2’-bipyridine were prepared by reacting [(η6 - C6H5CH3)Ru(µ-Cl)Cl]2 dimer with the N,N’-bidentate ligands in a 1:2 ratio. Characterization of the complexes was done using 1H NMR, elemental analyses, IR and UV/Vis spectroscopy. Electrochemical properties of the complexes were determined by cyclic voltammetry. Antimicrobial activities of the complexes and respective ligands were tested against drug resistant Gram-negative Escherichia coli ATCC 11775 and drug susceptible Gram-positive bacteria Staphylococcus aureus ATCC 12600. Some of the synthesized mononuclear ruthenium complexes demonstrated good potential antimicrobial activities against the selected bacteria tested with some showing better activity than well-known antibiotics such as streptomycin (S-10).
Authors and Affiliations
Margaret C. Koske, Stanley M. Kagwanja, Joel M. Gichumbi
Keywords
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- EP ID EP414412
- DOI 10.9790/5736-1110010611.
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