Synthesis, characterization of certain new heterocyclic hybrids of pyrazoles and evaluation of their anti-inflammatory activity
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2013, Vol 2, Issue 1
Abstract
The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activities like anti-inflammatory, antidepressant and anticonvulsant. As combination of biologically active moieties into one molecule and synthesis of totally newer moieties have been the methods of research, the present study is an attempt to synthesize some novel pyrazole derivatives, incorporating various biologically active aryl / aryloxy acid derivatives, such as ibuprofen, diclofenac, aceclofenac as well as potent antibacterial quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were evaluated for their anti-inflammatory (Carrageenan induced paw oedema method) activity. The results obtained were found to be compatible with standard literature and standard drug employed. Hence, the obtained derivatives can be subjected to further clinical studies to optimize their clinical efficacy.
Authors and Affiliations
Siddiqui Shakeel Ahmed
Keywords
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