Synthesis, Characterization,Antimicrobial Activityand Molecular Docking of a Dinuclear Nickel(II) Complex
Journal Title: International Journal Of Medical Science And Clinical Research Studies - Year 2022, Vol 2, Issue 08
Abstract
Bis-(benzidinedioxime)nickel(II) acetate complex was synthesizedby reacting the metal ions with benzidinedioxime in 1:1 mole ratio.The nickel(II) complex was characterized by elemental analysis, NMR, and powder X-ray diffraction.The result obtained from CHN Elemental analysis and 1H nuclear magnetic resonance confirmed that the nickel(II) complex is synthesized by reacting benzidinedioxime with nickel(II) acetate in a 1:1 mole ratio. The powder XRD showed that two Ni(II) coordinated to two benzidinedioxime ligands via the nitrogen atoms of both oxime groups and the two azomethine nitrogen atoms. Powder X-ray diffraction (PXRD) indicated that the nickel(II) complex has little distorted tetrahedral geometry. Nickel(II) complex has a higher antimicrobial activist against K. pneumonia, B. subtilis, and Candidathan kanamycin. In addition, theB. subtilis shows resistance against kanamycin (inhibition zone 0) while it shows high sensitivity against bis-benzidinedioxime nickel(II) acetatecomplex (inhibition zone 33.3 ± 0.82 mm, MIC 18.5 μg/mL). The average MICs of bis-benzidinedioxime nickel(II) acetate are found to be for inhibition of each of the five organisms in the range of 6.2–55.65 μg/mL. The molecular docking studies investigations confirmed that the bis-benzidinedioxime nickel(II) acetate is the most potent aminoglycoside enzymes bacterial inhibitors. The bis-benzidinedioxime nickel(II) acetate exhibited high binding energy with the receptor aminoglycoside-3-phosphotransferase enzyme than receptors of other aminoglycoside enzymes families
Authors and Affiliations
ReemM. A. Ebrahim,Nehad M. Abdul Aziz, Yousif Sulfab,Nahla Omer, ElmugdadA. Ali ,Emadeldin H. E. Konozy
Keywords
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- EP ID EP732189
- DOI 10.47191/ijmscrs/v2-i8-04
- Views 21
- Downloads 0
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