Synthesis of 3-(1H-1-imidazolyl)-2-methyl-4-chromanone as a pharmaceutical composition default by ?-bromo-2-hydroxy acetophenone
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2014, Vol 8, Issue 9
Abstract
The maximum range antifungal drugs are relatively limited impact, or due to toxicity, The lack of the potential for systemic use . Therefore, this study With the goal gain of antifungal With a wide And fewer drug interactions, seems to be necessary. Derivatives of 1-(2-hydroxy-phenyl)-2-(1H-1- Imidazolyl)-1-ethanol Undergo cycloaddition reaction is the whit Acetaldehyde And compound 3-(1H-1-Imidazolyl)-2-methyl-4-chromanone is prepared as azole drugs whit the potential effect of fungicide . Chemical structure built determined and confirmed By infrared spectroscopy, nuclear magnetic resonance and mass spectrometry . In order to differentiate and identify the trans Stereoisomers Between the two groups imidazole and methyl in the ring chromanone was used of the 1H NMR spectroscopy.
Authors and Affiliations
Jafar azimvand| Payam Noor University of Tehran
Keywords
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