Synthesis of Nanocomposition of Poly Acrylic Acid/Chitosan Coated-Magnetite Nanoparticles to Investigation of Interaction with BSA and IGG Proteins
Journal Title: International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Year 2017, Vol 3, Issue 1
Abstract
Among the nanomaterial being applied for treatment and diagnosis field, magnetic NPs especially magnetite phase of iron oxide have been significantly interested due to their natural magnetic properties. In this study, a nanocomposition of poly (acrylic acid) and chitosan with Fe3O4 NPs were prepared in order to investigation for drug delivery systems and plasma protein adsorption. Synthesized NPs were studied by various technics including XRD, TEM, SEM, FT-IR, VSM, DLS, zeta potential and AAS. These NPs have superparamagnetic property that is essential for magnetic NPs to applying in body and drug delivery. Plasma protein adsorption is one of the most important issues for failure of nanocarriers function. In this work, BSA and IgG were used as models of proteins to study adsorption of protein onto NPs by UV-Vis spectroscopy method. Adsorption behavior of NPs for each protein was different. PAA-Fe3O4 NPs represent the lowest albumin adsorption and can be expected that have lower adsorption of protein in the body. The release profile of ascorbic acid from PAA-Fe3O4 NPs represents no sensitivity to pH, and NPs showed approximately same release behavior in pH 7.4 and 5.8.
Authors and Affiliations
Shagholani Hamidreza, Ghoreishi Sayed Mehdi
Keywords
Related Articles
- EP ID EP335401
- DOI 10.17352/2455-3492.000018
- Views 43
- Downloads 0
Nanotechnology and Neutraceuticals
This paper provides an insight of some of the growing number of nano-applications being researched and commercialized in nutraceuticals. Recently, number of applications in dairy and food processing, preservation, packag...
Impetus in Fabrication of Biosensors
A biosensor is an element employed for the detection of an analyte by combining a biological component with a physico-chemical detector component. Biological component can be microorganisms, cell receptors, enzymes, anti...
Surface Enhanced Raman Scattering Spectroscopy for Pharmaceutical Determination
The rapid growth of pharmaceutical industries worldwide demands continuous development of efficient analytical techniques that help not only to detect the presence of the molecules at extremely low concentration levels,...
Combined In vitro Effects of TiO2 Nanoparticles and Dimethyl Sulfoxide (DMSO) on HepG2 Hepatocytes
Introduction: Professional workers that manufacture or use titanium dioxide (TiO2)-based paints are exposed to potentially toxic TiO2 nanomaterials as well as to different paint solvents such as dimethyl sulfoxide (DMSO)...
Two Faces of Curcumin; A Molecular Nutrition and an Anti-Cancer Agent
Curcumin, a useful herbal medicine with anti-inflammatory and anti-cancer properties is insoluble in water which restricts its therapeutic properties; its prominent application in cancer treatment is limited due to curcu...