Synthesis of Novel Methoxy Substituted Benzothiazole Derivatives and Antibacterial activity against Salmonella Typhi
Journal Title: Journal of Biological and chemical Chronicles - Year 2018, Vol 4, Issue 1
Abstract
Synthesis and screening of benzothiazole derivatives have great importance in heterocyclic chemistry because of its potent and significant biological activities against Salmonella (S) typhi especially methoxy substitution at benzothiazole. Methoxy substituted benzothiazole derivatives were synthesized by reaction of 3- chloro-4- methoxy-aniline with potassium thiocyanate under temperature control and presence of bromine in glacial acetic acid and ammonia. Substituted nitrobenzamides then synthesized by condensation of, 2-amino-4-chloro-5-methoxybenzothiazole with 2(3or4)-nitrobenzoylchloride acid in presence of dry pyridine and acetone. Finally, newly synthesized derivatives (K-01 to K-09) were synthesized through replacing of chlorine of nitrobenzamide by reaction with 2-nitroaniline, 3-nitroaniline, and 4-nitroaniline in presence of DMF. Analytical characterization was performed by TLC, melting point, IR and NMR spectral study. Antibacterial activity was performed against S. typhi by cup plate method (diffusion technique) using procaine penicillin as standard. Compound K-03 and K-05 showed potent antibacterial activity against S. typhi at both concentrations 50μg/ml and 100μg/ml as compared to standard.
Authors and Affiliations
Akhilesh Gupta
Keywords
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