SYNTHESIS OF ORGANOTIN POLY(AMINE ETHERS) FROM THE HIV DRUG LAMIVUDINE (3TC)
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 9
Abstract
Organotin poly(amine ethers) were rapidly synthesized in good yield employing the interfacial polycondensation system. Yield increases as the size of the alkyl group on the tin increases. Synthesis employed commercially available reactants allowing for ready production in gram to kilogram quantities. Infrared spectroscopy showed the formation of new bands characteristic of the Sn-O- and Sn-N linkages. MALDI MS shows ion fragment clusters to nine and ten units in length. The polymers exhibit decent inhibition of all of the tested human cancer cell lines including two human pancreatic, two human breast and two human glioblastoma brain cancer cell lines.
Authors and Affiliations
Charles E. Carraher Jr.
Keywords
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