SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 1
Abstract
2-Amino-1-aryl-1, 4, 5, 6, 7, 8-hexahydro-4-phenyl-quinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidine-malononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. Also, the antimicrobial activity of the newly synthesized derivatives was reported.
Authors and Affiliations
Sherif M. Sherif et al.
Keywords
Related Articles
- EP ID EP554716
- DOI -
- Views 71
- Downloads 0
PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL SCREENING OF LEAVES OF RAPHANUS SATIVUS, LINN.
Raphanus sativus commonly known as radish is cultivated as a crop and having various medicinal uses. It is cultivated all over the world as an edible root vegetable. The present study deals with the pharmacognostic, prel...
EVALUATION OF ANALGESIC ACTIVITY OF THE DIFFERENT FRACTIONS OF TYPHA ELEPHANTINA ROXB.
This study was aimed to investigate the analgesic activity of the different fractions of Typha elephantina Roxb. Analgesic activity was evaluated for peripheral pharmacological actions using the acetic acid-induced writh...
PHYTOPHARMACOGNOSTICAL INVESTIGATION OF SAMASARKARA CHURNA
Introduction: Samasarkara churna is the Ayurvedic medication preferred treatment of dyspepsia, loss of appetite and piles, formulated by mixing powder of cardamoms, long piper, black piper, flowers of Mesua ferrea, cinna...
PHYTOCHEMICAL AND ANTIBACTERIAL POTENTIAL OF ACETONE LEAF EXTRACT OF ACACIA CONCINNA (WILLD.) DC.
The present study was aimed to find out the antimicrobial potential of acetone extract of Acacia concinna leaf against five different bacterial strains at 100 and 200mg/ml concentrations. The disc diffusion assay was per...
ANTIPROLIFERATIVE ACTIVITY OF THREE WILD GROWING SPECIES IN TUNISIA: NICOTIANA GLAUCA, ARTEMISIA CAMPESTRIS AND ASTRAGALUS GOMBO
Tunisian flora contains a number of wild plants with diverse therapeutic uses. As a contribution to the efforts to select natural sources of antitumor compounds, we investigated in this study the Antiproliferative activi...