SYNTHETIC APPROACH TOWARDS PYRIMIDO [4, 5-B] QUINOLINE WITH 2-SUBSTITUTED DERIVATIVES AND STUDY OF ANTIMICROBIAL ACTIVITY
Journal Title: Journal of Atoms and Molecules - Year 2012, Vol 2, Issue 4
Abstract
2-Amino-8-nitropyrimido[4,5-b]quinoline (1) and ethyl 2-cyano-3,3-bis(methylthio)acrylate (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3-cyano-8-nitro-2- (methylthio) -4-oxo- 4H- pyrimido [2,1-b] pyrimido [4,5-b] quinoline (3). The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl groups. Afforded to 3-cyano-8-nitro- 4- oxo- 4H- pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities.
Authors and Affiliations
Sambhaji P. Vartale, Nilesh K. Halikar, Prashant N. Ubale, Niwrati S. Pawar
Keywords
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