System pharmacology-based dissection of the potential effective material basis and mechanism of Xiaoxianxiong decoction for type 2 diabetes mellitus
Journal Title: Traditional Medicine Research - Year 2021, Vol 6, Issue 4
Abstract
Background: Xiaoxianxiong decoction is a classic formula in traditional Chinese medicine used to treat type 2 diabetes mellitus and proven to be effective. But the material basis and underlying mechanisms remain unclear. The aim of the present study was to elucidate the potential effective material basis of Xiaoxianxiong decoction and molecular mechanism treating type 2 diabetes mellitus. Methods: The absorbed bioactive components were identified based on serum pharmacochemistry. Network analysis were performed to obtain effect targets for docking verification with the absorbed prototypes to determine the potential effective material basis. On the above basis, network pharmacology was conducted to explore the molecular mechanism. Results: 76 compounds were identified of Xiaoxianxiong decoction and 61 absorbed bioactive compounds were investigated. Serine/threonine kinase 1 and ALB were key targets acquired by network analysis for molecular docking. Subsequently, 5 compounds were considered as the potential effective material basis, namely berberine, berberrubine, lariciresinol and gingerenone A, jatrorrhizine. Further, the mechanism mainly lies in the insulin signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway, AGE-RAGE signaling pathway in diabetic complications, phospholipase D signaling pathway to regulate blood glucose levels on target tissues as well as organs and exhibit anti-inflammatory, promote cell differentiation and cell growth, maintain oxygen homeostasis and affect the enzymes along with key metabolites. Conclusion: This integrated research strategy to investigate the treatment of Xiaoxianxiong decoction on type 2 diabetes mellitus provides valuable insights for further study and clinical practice of Xiaoxianxiong decoction.
Authors and Affiliations
Jiao Kong, Chuan-Xin Liu, Jia-Li Zhou, You-Zhi Li, Xi-Xi Cui, Tao He, Bao-Nan Ma, Shuang Han, Yi-Ning Zhang, Jian-Mei Huang
Keywords
Related Articles
- EP ID EP695480
- DOI 10.12032/TMR20201221213
- Views 161
- Downloads 0
A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions
Objective: To find out the potential mechanisms of Si-Jun-Zi (SJZ) decoction in the treatment of gastric precancerous lesions (GPL). Methods: A network pharmacology approach was used to analyze the active compounds, drug...
Dry cupping therapy and the wellness management of health travelers
Objective: Individuals travel locally and internationally in order to find alternative treatments which are less-toxic and more beneficial to their health and wellness. Despite the popularity of the western system of med...
Effects of herbal medicine in gastroesophageal reflux disease symptoms: a systematic review and meta-analysis
Background: Pyrosis and regurgitation are the cardinal symptoms of gastroesophageal reflux disease. Several herbs have been used for treating gastrointestinal disorders worldwide. This systematic review was conducted to...
Bibliometric analysis of acupuncture research through the Web of Science database from 1990 to 2019
Background: The main points of focus of bibliometric analysis of acupuncture treatment of diseases include pain (headache, low back pain), insomnia, and knee osteoarthritis, for example. In this paper, we analyze the fro...
Study on the relationship between the structure of bacterial flora on the tongue and types of tongue coating in patients with type 2 diabetes mellitus
Highlights The incidence of type 2 diabetes mellitus (T2DM) is related to the imbalance of oral microflora in the human body. The characteristic tongue coating flora structure, containing Prevotella, Fusobacterium, St...