A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions
Journal Title: Traditional Medicine Research - Year 2018, Vol 3, Issue 6
Abstract
Objective: To find out the potential mechanisms of Si-Jun-Zi (SJZ) decoction in the treatment of gastric precancerous lesions (GPL). Methods: A network pharmacology approach was used to analyze the active compounds, drug targets and interacting pathways of SJZ decoction in treating GPL. The compounds and predicted targets of SJZ decoction were screened from TCMSP, and the disease targets were obtained from GeneCards. The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology (GO) enrichment, Kyoto encyclopedia of genes and genomes pathway enrichment analyses. Results: The results show that 111 compounds and 90 targets were obtained in this work. These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways. Active compounds, targets, and pathways were used to construct a compound-target network, a target-pathways network, and an integrated GPL pathway. These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation. Conclusion: This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction, which facilitate the modernization of herbal medicine for complex diseases in the future.
Authors and Affiliations
Liang-Jun Yang, Dao-Rui Hou, Ya Li, Zhi-Peng Hu, Yong Zhang
Keywords
Related Articles
- EP ID EP45174
- DOI 10.12032/TMR201814087
- Views 284
- Downloads 0
Optimized extraction and purification technology of Gekko sulfated glycopeptide based on its anticancer activities
Objective: To optimize the extraction and purification technologies of Gekko sulfated glycopeptide based on the content of glycopeptide, removal ratio of proteins, and anticancer activities. Methods: Different extraction...
Treatment of diabetic foot ulcer with medicinal leech therapy and honey curcumin dressing: a case report
Highlights Wound healing impairment and ulcers in the foot, with pain and disability, are common complications of diabetes. The present case report shows the effectiveness of leech therapy in combination with honey an...
Investigation of in vitro antioxidant activity of dihydromyricetin and flavonoids rich extract from vine tea (Ampelopsis grossedentata)
Background: Vine tea from fermented Ampelopsis grossedentata leaves has been used as a herbal tea and folk medicine in the southern region of China for hundreds of years. The aim of this investigation was to analyze the...
Study on alantolactone-induced differentiation of mesenchymal stem cells into vascular cells
To promote efficient screening of active angiogenic drugs from traditional medicines, we constructed a human embryonic kidney-293 cell model using vascular endothelial growth factor (VEGF) gene promoter as the drug targe...
The effect of acupuncture plus drug versus drug alone on patients with mild cognitive impairment: a systematic review
Objective:The aim of this systematic review is to evaluate the effect of acupuncture plus drug versus drug alone on patients with MCI.Methods:A computerized search of the databaseswas performed from inception through Feb...