Systemic Effects of Nigerian Bituminous Coal Fly Ash in Albino Rats: Serum Biochemistry and Histopathological Evaluation
Journal Title: International Journal of Biochemistry Research & Review - Year 2017, Vol 20, Issue 2
Abstract
In this study, the in vivo toxicity index of Nigerian bituminous coal fly ash prepared under a burning temperature of 900ºC was evaluated following oral administration to Albino rats. The effect of the sample prepared at this temperature was compared under various dose (100, 200 and 500 mg/kg body weight) concentrations and systematically relate the effect on the serum electrolytes (Na+, K+, Cl-, HCO-3) activity levels, the liver enzymes (ASAT, ALAT, SAP), Total bilirubin (TB), Total protein (TP) and Albumin (ALB) respectively. From the results, the fly ash was observed to induced significant alteration in the TB, TP and ALB concentrations in both study periods, with no apparent disturbances recorded in the liver enzymes and serum electrolyte concentrations when compared to the control. Furthermore, the fly ash was observed to profoundly induce pathological lesion in the lungs and the intestine, with mild histological changes observed in the liver and spleen. While, no significant changes observed in the kidney in the primary study, the fly ash in the secondary study was observed to induce tubular degeneration in the kidney. The results further showed that, the Nigerian bituminous coal fly ash, irrespective of the treatment groups demonstrated a time-dependent effects histologically and in serum biochemistry profiles. Thus, further confirmed that, the reactivity of the coal fly ash, though independent of the sampling dose might be attributed to the organic and inorganic constituents in the fly ash interacting with the rat’s normal metabolic pathways, initiating and triggering toxic-induced effects histological and physiologically. The results further provide us with additional information on the in vivo effects and susceptibility of Nigerian bituminous coal fly ash and the need to explore same for energy generation under control and regulated combustion processes.
Authors and Affiliations
I. B. Bwatanglang, S. H. Garba, I. D. Lynna, D. Y. Shinggu, T. S. Magili, Y. Musa
Keywords
Related Articles
- EP ID EP317026
- DOI 10.9734/IJBCRR/2017/38602
- Views 121
- Downloads 0
Water Stress Effect on Total Antioxiant Activity and Total Phenolic Content of Solanum scabrum Mill and Solanum scabrum in Kiambu, Kenya
Aims: The aims of this study were to investigate water stress effect on total phenolics and total antioxidants of selected African nightshades and determine any possible variations in the amount of total phenolics and to...
Effect of Grinding Plates (GUK, Parpela and Premier) on Maize Flour Milled within Samaru, Nigeria
This research work was carried out to determine the concentration of Cu, Mn, Pb and Fe in maize flour milled by different types of milling plates in Samaru, Zaria, Nigeria. Three different types of milling plates with th...
Circulating Survivin and TIMP-1 in Hepatitis C Virus Associated Liver Fibrosis
Aims: The present study was conducted to assess the clinical utility of survivin, an anti-apoptotic protein, and the profibrogenic tissue inhibitor metalloproteinase-1 (TIMP-1) as non-invasive biomarkers for the discrimi...
Hypolipidemic Activity of Fermented Sorghum (Sorghum bicolor L. Moench) Gruel (Ogi) in Hypercholesterolemic Rats (Rattus nervegicus)
Background: Fermented gruel (Ogi) has been reported to have high lactic acid bacteria (LAB) with proven probiotic properties. This fermented food has also has different therapeutic usages. Objective: The activities of f...
Ameliorative Potentials of Egg Plant (Solanum melongena Linn) Fruit Ethanolic Extract on Monosodium Glutamate- Intoxicated Rats' Lipid Profile, Haematology and Heart Histology
Aim: This study evaluated the ameliorative potentials of ethanolic extract of Solanum melongena Linn fruit on monosodium glutamate (MSG)-intoxicated rats' lipid profile, haematological parameters and heart histology usin...