Systemic Inflammatory Markers as Predictor of Severity of Chronic Obstructive Pulmonary Disease (COPD) A Case - Control Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: COPD is a systemic inflammatory disorder in which systemic inflammation contributes to the various systemic effects of the disease. The disease is associated with low-grade systemic inflammation which is multifactorial in origin. The identification of these factors need to be established and their relative importance in causation to be identified. The aim of the study was to understand the pathogenesis and to see the relationship of systemic inflammatory markers with the severity of COPD in our population in which the prevalence of this disease is high. Material and methods: In this prospective case control study, 55 stable COPD patients(GOLD stage I-IV) of both genders were compared with 55 normal healthy age and sex matched controls. The mean age of the patients was 60.2±7.385 (range 40-80 years) and that of controls 57.35±6.174 (range 40-78 years). Males constituted 69.10% in cases and 80.00% in controls. Serum hs- CRP and TNF-α levels were measured in both groups by Elisa method. Quantitative data was analysed by using two sample independent t-test and analysis of variance and categorical data was analysed using Pearson chi-square / Fischer’s exact test using SPSS-17 software. P-value of less than 0.05 was considered to be statistically significant. Results: The mean levels of hs-CRP were significantly higher in cases than in controls (5005.6 and 950.9 ng/ml respectively; p-values = 0.0001). Similarly the mean levels of TNF-α were higher in cases compared to controls (337.4 and 137.85 pg/ ml; p-values = 0.0001). Mean levels of hs-CRP and TNF-α both increased with increase in stage of the disease which was statistically significant (p-value= 0.0001 and 0.0001respectively). Patients having metabolic syndrome had significantly higher hs- CRP and TNF-α levels compared to patients without metabolic syndrome irrespective of stage of disease (p-value of = 0.0001). Conclusion: Systemic inflammation is more in COPD patients and it increases with increase in severity of the disease. Metabolic syndrome further increases systemic inflammatory process that is already there as a result of COPD
Authors and Affiliations
Suhail Mantoo, Umar Hafiz Khan, Mohamad Akbar Shah, Syed Mudasir Qadri, Abdul Waheed Mir, Zaffar Amin Shah, Sonaullah Shah
Keywords
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