Systemic therapy options in malignant bone diseases
Journal Title: Ortopedia Traumatologia Rehabilitacja - Year 2005, Vol 7, Issue 5
Abstract
Bone metastases (secondary bone neoplasms) represent a more significant epidemiological problem than primary bone neoplasms. The differing histogenesis of primary and secondary malignant bone neoplasms (respectively, mesenchymal and epithelial origin) influences the variability of activity and indications for systemic therapy. A common response is the use of systemic therapy within a multidisciplinary therapeutic approach. The principles of chemotherapy used for primary bone neoplasms are essentially similar in spindle-cell and small-cell sarcomas. Initial multi-drug chemotherapy should be administered in all stages. Chemotherapy may also be used following local treatment, although the role of adjuvant chemotherapy is better defined in small-cell sarcomas. Chemotherapy is also applied in the palliative management of disseminated sarcomas.Systemic therapy plays an essential role in the management of patients with bone metastases during the course of breast and prostate carcinoma. The use of hormonal therapy is based on endocrine dependency of both malignancies. Chemotherapy represents a treatment of choice in several clinical situations due to high chemosensitivity of the underlying malignancy (e. g., small-cell lung cancer or lymphoma). Bisphosphonates play an important role in the management of bone metastases. The use of bisphosphonates is most justified in patients with breast cancer, multiple myeloma, and prostate carcinoma.
Authors and Affiliations
Maciej Krzakowski
Keywords
Related Articles
- EP ID EP56376
- DOI -
- Views 87
- Downloads 0
Ocena skuteczności osocza bogatopłytkowego w leczeniu przewlekłego zespołu bólowego przyczepu ścięgien mięśni „gęsiej stopy”
Wstęp. Zespoły bólowe przyczepów mięśniowych nie dotyczą tylko i wyłącznie sportowców, ale również osób o przeciętnej aktywności życiowej. Powtarzające się mikrourazy w obrębie gęsiej stopy mogą doprowadzić do przewlekłe...
Analysis of Risk Factors for Periprosthetic Joint Infection in Clinical Data
Background. Progress in orthopaedics has now made it possible to improve the functional status of damaged hip joints with hip arthroplasty and eliminate the associated pain. The constantly growing number of hip replaceme...
Dymorfizm płciowy w budowie panewki stawu biodrowego na podstawie badań 3D tomografii komputerowej miednic
[b]Wstęp. [/b]Prezentowane badanie ma na celu porównanie różnic płciowych w budowie i w przestrzennym ustawieniu panewek miednicy, w celu lepszego zrozumienia anatomii stawu biodrowego.[b]Materiał i metody. [/b]Badanie w...
Evaluation of Selected Gait Parameters in Patients Prior to and at 6 Months Following Early Anterior Cruciate Ligament Reconstruction
[b]Background. [/b]ACL rupture and reconstruction may lead to impairment of spatiotemporal and kinematic gait parameters. The purpose of this study was to evaluate patient’s gait following a complete tear of the ACL and...
Ankle Arthrodesis Using the Ilizarov Technique in Difficult Situations - a Prospective Study with Mid-to Long-term Follow up
Background. Although various operative techniques are available for ankle arthrodesis, it is not rare to see orthopaedic surgeons facing difficult situations with ankles that cannot be reliably treated by any conventiona...