T1 Mapping for Quantifying Myocardial Viability in the Peri-Infarct Regions
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 8, Issue 1
Abstract
While the advances in revascularization therapy have drastically decreased the mortality following ST elevation myocardial infarction (STEMI), the number of patients who develops heart failure (HF) following the reperfusion therapy continues to rise. More than 30% of the patients who survive STEMI develop HF long term [1]. In addition, patients with a history of acute myocardial infarction (AMI) and left ventricular (LV) dysfunction have a markedly increased 6 months mortality of greater than 10% [2] Thus, there is an urgent unmet clinical need to clarify the mechanisms of SCD and HF post-MI and develop a robust biomarker to identify the high-risk patients. The importance of differentiating the peri-infarct region (PIR) from the adjacent non-viable infarct core (IC) has been noted recently as it could independently determine the occurrence of major adverse clinical events [3,4]. The PIR consisting of heterogeneous tissue components represents the nexus for active remodeling or repair characterized by extracellular matrix formation, angiogenesis, oxidative stress, mitochondrial energetics, apoptosis and inflammation [5,6]. We here review the non-invasive MRI approaches to characterize PIR.
Authors and Affiliations
Yuko Tada, Phillip C Yang
Keywords
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- EP ID EP588446
- DOI 10.26717/BJSTR.2018.08.001608
- Views 174
- Downloads 0
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