Targeting Immune-Evasion Mechanisms as a Possible New Approach in the Fight against Tuberculosis
Journal Title: Immunological Disorders and Immunotherapy - Year 2015, Vol 1, Issue 1
Abstract
The emergence of multidrug resistant Mycobacterium tuberculosis (Mtb) strains, the difficulties in the development of new safe therapies or the production of a protective vaccine against tuberculosis make the study of the strategies developed by Mtb to escape from the host immune system an important source of potential targets of immunointervention in the fight against tuberculosis. A mechanism of immune-evasion specific for the post-primary tuberculosis based on the differentiation of disabled antigen presenting cells is described
Authors and Affiliations
Roberto Nisini
Keywords
Related Articles
- EP ID EP743466
- DOI -
- Views 20
- Downloads 0
TMEM4 is Highly Expressed in Plasma Cell Neoplasms and Associated with B Lymphocyte Differentiation
Aiming to identify biomarkers for plasma cell neoplasms, we analyzed gene expression profile and proteomic characteristics of mouse models of plasmacytomas along with other types of B-cell neoplasms. We found that transm...
MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines
The MHC class I related chain A and B have been of much interest in the recent past. MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells a...
Targeting Immune-Evasion Mechanisms as a Possible New Approach in the Fight against Tuberculosis
The emergence of multidrug resistant Mycobacterium tuberculosis (Mtb) strains, the difficulties in the development of new safe therapies or the production of a protective vaccine against tuberculosis make the study of th...
Bilateral Choroidal Metastasis as Initial Presentation of Parotid Gland Adenoid Cystic Carcinoma
Choroidal metastasis rarely reveals a primary cancer. At this stage, they are associated with multiple metastases. Adenoid cystic carcinoma also known as cylindroma is very rare and constitutes 1% of major and minor sali...
Unique COVID/Anti-Spike Protein Immune Responses in Two Elderly Patients without COVID-19 Vaccination
Published reports continue to emerge regarding different health outcomes in patients immunized and not immunized against the SARS-CoV-2 antigen (i.e., spike protein) that were infected with the virus. Because of the vast...