MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines
Journal Title: Immunological Disorders and Immunotherapy - Year 2016, Vol 1, Issue 1
Abstract
The MHC class I related chain A and B have been of much interest in the recent past. MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells are effector cells of the innate immune system and their functions are regulated by a number of killer cell-inhibitory and -activating receptors.).Their expression on normal tissues is highly restricted but in the event of tissue transformation and infected cells, MICA/B expression is up-regulated leading to NK killing activity. MICA/B are shedded in the serum of cancer patients (sMICA/B) whereby sustained expression of this MIC affects the killing activity of NK cells and T cells. In this summary review we look at how differently MIC A/B is expressed in Cancer cell.
Authors and Affiliations
OREMO JAA, Zhang Xiao and Zhu Sha
Keywords
Related Articles
- EP ID EP743468
- DOI -
- Views 9
- Downloads 0
Targeting Immune-Evasion Mechanisms as a Possible New Approach in the Fight against Tuberculosis
The emergence of multidrug resistant Mycobacterium tuberculosis (Mtb) strains, the difficulties in the development of new safe therapies or the production of a protective vaccine against tuberculosis make the study of th...
TMEM4 is Highly Expressed in Plasma Cell Neoplasms and Associated with B Lymphocyte Differentiation
Aiming to identify biomarkers for plasma cell neoplasms, we analyzed gene expression profile and proteomic characteristics of mouse models of plasmacytomas along with other types of B-cell neoplasms. We found that transm...
Bilateral Choroidal Metastasis as Initial Presentation of Parotid Gland Adenoid Cystic Carcinoma
Choroidal metastasis rarely reveals a primary cancer. At this stage, they are associated with multiple metastases. Adenoid cystic carcinoma also known as cylindroma is very rare and constitutes 1% of major and minor sali...
Th1 Cytokine Profile Associated of Severe Malaria Resistance In Endemic Areas
Introduction: Malaria, a disease caused by protozoan parasites of the genus Plasmodium. Despite the premunition, some adults still experience the severe form of malaria. The study hereby aims to investigate the involveme...
A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance
In this report, investigations were done to study human GULP/ CED 6 genes role in presenting cancer cells to scavenger cells. CED 6 SiRNA was used to knock out the gene in Astrocytoma (HTB-12) cell lines to study its eff...