Th1 Cytokine Profile Associated of Severe Malaria Resistance In Endemic Areas
Journal Title: Immunological Disorders and Immunotherapy - Year 2018, Vol 3, Issue 2
Abstract
Introduction: Malaria, a disease caused by protozoan parasites of the genus Plasmodium. Despite the premunition, some adults still experience the severe form of malaria. The study hereby aims to investigate the involvement of Th1 cytokines profile in the resistance to severe malaria in endemic areas. Patients and methods: It was a prospective study with an analytical focus on a 3-year period from July 30, 2015 to February 23, 2018. The study covered 150 patients, 50 patients suffering from simple malaria, 50 others hospitalized for the severe form and 50 witnesses. All the analyzes were performed within the Immunology Laboratory of the University Hospital of Cocody. Results: It is clear that, the average level of antibody according to the clinical status is meaningless, and Th1 cytokine levels (TNFα, INFγ, IL-12) are highest in severe malaria compared to simple malaria and witnesses. Moreover, there is no correlation between the average level of Th1 cytokines and the average rates of antibodies. Conclusion: Severe adult malaria in endemic areas is associated with cellular immunity and this is not dependent of the premunition and acquisition of IgG antibodies.
Authors and Affiliations
Tariam Djibangar Agnès, Romuald Dassé Séry, Richard Yéboah Oppong, Adjoumanvoulé Honoré Adou, Sansan Hien, Amah Patricia Victorine Goran-Kouacou, Koffi N’Guessan, Sombo Mambo François, Kouabla Liliane Siransy, Babacar Mbengue and Alioune Dieye
Keywords
Related Articles
- EP ID EP743459
- DOI -
- Views 30
- Downloads 0
Are TEM and CTX Beta-Lactamase Genes Common among Urinary Isolates from Ain Shams Hospital Intensive Care units?
The extended- spectrum β-lactamase producing Gram Negative bacteria are widely spread worldwide. Productions of these enzymes cause bacterial resistance to beta-lactam antibiotics as penicillin and cephalosporins. These...
https://www.longdom.org/open-access/differential-gene-expression-of-threatened-himalayan-snow-trout-challengedwith-aeromonashydrophilla-84987.html
Objective: Curcuma has long been used as a Chinese herbal medicine for the treatment of chronic liver disease, and curcumol is its main active ingredient. This study explores the molecular mechanism of curcumol regulatin...
Targeting Immune-Evasion Mechanisms as a Possible New Approach in the Fight against Tuberculosis
The emergence of multidrug resistant Mycobacterium tuberculosis (Mtb) strains, the difficulties in the development of new safe therapies or the production of a protective vaccine against tuberculosis make the study of th...
Curcumol Targets Gls1 to Regulate Glutamine Metabolism and Induce Senescence of Hepatic Stellate Cells to Exert Anti-Hepatic Fibrosis Mechanism
Objective: Curcuma has long been used as a Chinese herbal medicine for the treatment of chronic liver disease, and curcumol is its main active ingredient. This study explores the molecular mechanism of curcumol regulatin...
TMEM4 is Highly Expressed in Plasma Cell Neoplasms and Associated with B Lymphocyte Differentiation
Aiming to identify biomarkers for plasma cell neoplasms, we analyzed gene expression profile and proteomic characteristics of mouse models of plasmacytomas along with other types of B-cell neoplasms. We found that transm...