TARGETING SEROTONERGIC PATHWAY FOR ANTI-AMNESIC ACTIVITY BY MORUS ALBA L.
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 1
Abstract
The present study aimed to evaluate the anti-amnesic potential of ethyl acetate soluble fraction of methanolic extract of Morus alba L (EASF). The effect of EASF of Morus alba on learning and memory was evaluated by using object recognition test (ORT), elevated plus maze (EPM) and water maze test (WMT). EASF was administrated in doses of 25, 50 and 100 mg/kg p.o. Scopolamine (1 mg/kg, i.p.) was used to induce impairment in memory. The effect of EASF was also studied on serotonin–induced contractions of isolated rat fundus. EASF significantly improved discrimination index (DI) in ORT. Pretreatment with EASF significantly increased transfer latency (TL) and swimming time in target quadrant in EPM and WMT respectively. The result of the in-vitro study showed that EASF inhibited serotonin-induced contractions on rat fundus, possessing anti-serotonergic activity. Thus, the present study revealed that EASF of M. alba has significantly improved learning and memory through its anti-serotonergic mechanism. Morus alba may be useful for the treatment of dementia and other cognitive disorders.
Authors and Affiliations
V. S. Nade, L. A. Kawale
Keywords
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