TECHNOLOGY OF PREPARATION AND EVALUATION OF KETOPROFEN-CHITOSAN SOLID DISPERSION
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
The aim of the study was to investigate the effect of chitosan on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in physical mixtures at the drug to polymer ratios of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; the mean amount of dissolved ketoprofen and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multifold increase (33 times) in ketoprofen solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of ketoprofen in the presence of chitosan at the weight ratio 1:9 increased with the decrease of the molecular weight of the chitosan. The results obtained may help to develop new technologies for ketoprofen preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Authors and Affiliations
Bożena Grimling, Maria Szcześniak, Jan Meler, Janusz Pluta
Keywords
Related Articles
- EP ID EP73397
- DOI 10.15259/PCACD.19.02
- Views 83
- Downloads 0
IN VITRO STUDIES OF ADSORPTION OF ERYTHROMYCIN ON CHITOSANS FROM DIETARY SUPPLEMENTS
In clinical practice, in the treatment of obesity, a plurality of natural high-molecular compounds are used, the activity of which supports weight loss. During the use of dietary supplements containing chitosan, illness...
INFLUENCE OF A CALCIUM ALGINATE ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
Treatment of vagina inflammatory condition is usually long and difficult because of its frequent relapse. The investigated preparations on methylcellulose base revealed good adhesion to the vaginal mucosa and were presen...
MECHANISM OF FORMATION OF THERMOSENSITIVE CHITOSAN CHLORIDE GELS
In these studies, an attempt has been made to explain the mechanism of gel formation. The studies were carried out to develop the mechanism of chitosan gel formation in the presence of glycerol phosphate GP, taking into...
CYCLICAL METAL ADSORPTION AND DESORPTION THROUGH SLUDGE IMMOBILIZED IN CHITOSAN MEDIA
In this research, a cyclical adsorption/desorption of cadmium and zinc from solutions containing a single metal or its mixture in ratio of 1:1 and 1:2 using immobilized activated sludge in the chitosan (ASC) was examined...
STATE OF WATER IN CITRATE CROSSLINKED CHITOSAN MEMBRANE
The ionically crosslinked membranes were prepared of chitosan (Ch) and trisodium citrate (Ch/CIT). The characteristics of the state of water in crosslinked and uncrosslinked chitosan membranes with different water conten...