TENOFOVIR INDUCED HEPATITIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 43
Abstract
PRESENTATION OF CASE A 23-year-old sero-positive male on TLE (Tenofovir, Lamivudine, Efavirenz) regimen for 8 months was admitted under medicine care with complaints of yellowish discolouration of eyes and skin, abdominal bloating, nausea and decreased appetite in the last 3 months. The use of Highly Active Anti-Retroviral Therapy (HAART) for management of HIV seropositive patients has brought about radical enhancement in their lifespan and quality of life. Recognising the side effects and toxicity of long-term use of ART is crucial for their management. Tenofovir is a nucleotide analog reverse-transcriptase inhibitor (NtRTI) and cases of Tenofovir induced hepatitis are rare. However, a majority of NtRTIs can induce mitochondrial damage and therefore have potential for liver damage. Here, we report a rare case of tenofovir causing hepatitis in a patient with none of the recognisable risk factors who is seropositive.
Authors and Affiliations
Hemant R. Gupta, Nishi Vishwanathan, Minal A. Meshram
Keywords
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- EP ID EP548975
- DOI 10.14260/jemds/2018/1046
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