Testicular Seminomas: Evaluation of 34 Cases with Histopathological Parametres.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Introduction: Testicular tumors are rarely seen, accounting for 1-2% of malignant tumors in males and 13-23% of male urogenital system tumors. They are usually seen between the ages of 15-45. Germ cell neoplasia in situ (GCNIS) is considered to be the precursor of all testicular germ cell tumors except spermatocytic seminoma. Seminoma is the most common germ cell tumor of the testis. Pure seminoma constitutes approximately 50% of all testicular germ cell tumors. Seminomatous germ cell tumors consist of seminoma and spermatocytic seminoma according to the 2004 World Health Organization classification. In addition, the sincytiotrophoblastic giant cell variant of the seminoma and the sarcomatous component variant of the spermatocytic seminoma are included in the classification. Materıal and method: H & E stained slides of 34 cases of seminoma diagnosed in the Department of Pathology of Izmir Training and Research Hospital between 1989-1999 were re-examined and classified according to 2004 World Health Organization classification. Histopathological parameters of the cases were reviewed. PAS and PAS diastase stains were applied to evaluate the glycogen content of the tumor in all cases. In addition, PAS was applied to investigate the presence of ITGCNU in slides containing non-tumoral testicular tissue and the diagnostic usefulness of PAS stain was evaluated. Results: Thirty-four cases of seminoma included in our study were evaluated as seminoma (n = 25; 73.5% ), a variant of seminoma containing syncytiotrophoblastic cells (n=8; 23.5%), and spermatocytic seminoma (n=1. 3%). The mean age of the patients was 40.1 (16-72) years. The mean tumor size was 6.4 cm (1.1-15 cm). GCNIS was observed in samples obtained from non-tumoral testicular tissue of 13 (52%) of 25 patients Conclusion: The histopathological features of the tumors in our series are largely consistent with the literature. In all cases with presumptive diagnosis of GCNIS based on H & E stained sections was also confirmed by PAS staining.
Authors and Affiliations
Dr. Duygu Ayaz
Keywords
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