Testosterone Level and Insulin Sensitivity among Sudanese Males Patients with Type 2 Diabetes Mellitus in Khartoum state
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background: Type 2 diabetes mellitusis the most common disease affecting the human,is a long term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin Objectives: The aim of this study to asses' testosterone level and insulin sensitivity among Sudanese males patients with type 2 diabetes mellitus. Methods: Cross sectional, case control study was conducted during the period from November to December 2016, sixty samples from known patients with type2 DM and sixty samples from healthy persons as control. The levels of testosterone, insulin and insulin sensitivity were measured using TOSOH 360. Data were collected using structural questionnaire. Data analysis was carried out by means of statistical package for social science (SPSS version 16). Results: The mean level of testosterone showed significant decreased in case when compared with control group. Mean ± SD cases versus control group (3.70±2.02 verse 5.64±1.52ng/ml, P- value = 0.000). There were significant increased of insulin level and insulin sensitivity in type 2 diabetic patients when compared to control group. (10.43±8.34 verse 7.20±1.62 µ u/ ml, p- value = 0.000) (4.08±2.34 verse1.66±0.51, p- value = 0.003) respectively. The result showed there was significant weak negative correlation between testosterone level and insulin sensitivity (r=-0.271, p-value=0.036), also there was significant weak negative correlation between testosterone and insulin level(r=-0.235,p, value =0.23) . There was negative correlation between testosterone level and age group (r= -0.302 p, value =0.019) and there was negative correlation between testosterone level and duration of disease (r= -0.325 p, value =0.011) , while there was significant positive correlation between insulin levels and duration of type2 DM (r=0.320, p, value=0.013). Conclusion: It concluded that, the level of testosterone was decrease and the levels of insulin and insulin sensitivity were significant increase in type 2 diabetic patients.
Authors and Affiliations
MarwaMohammedJebreel Albalal, NuhaEljailiAbubaker Noon Babiker Mohammed Ahmed
Keywords
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