The Ameliorating Effect of Vitamin C against Cardiopulmonary Toxicity of Zinc Oxide Nanoparticals
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2015, Vol 9, Issue 7
Abstract
It has demonstrated that nanoparticles may cause more inflammation than larger particles of the same materials at a same mass dose. The aim of this study was to investigate the ameliorating effect of vitamin C against cardiopulmonary toxicity of zinc oxide nanoparticals. Animals were divided into 4 groups, group I received vehicle orally for four weeks. Group II received vitamin C orally in a dose of (30 mg/kg) daily orally for four weeks. Group III received zinc oxide nano-particles orally in a dose 1 g/kg body weight/day for two weeks. Group IV received zinc oxide nano-particles orally in a dose 1 g/kg body weight/day for 14 days, co-administered vitamin C (30 mg/kg) daily orally, to be followed by two weeks vitamin C only (30 mg/kg) daily. Cardiac biomarkers troponin-T, lactate dehydrogenase (LDH), creatinine kinase (CK), and aspartate transaminase (AST) ) were measured. Finally, histopathological studies were performed from hear and lung sections of all rats of all groups. The results showed that administration of repeated doses of ZnO-NPs to rats significantly increased heart function biomarkers. Co-administration of vitamin C significantly reversed these changes to almost normal. Apart from these, histopathological changes also revealed the protective nature of vitamin C against ZnO-NPs induced necrotic damage of the heart and lung tissues.
Authors and Affiliations
Dalal Nemenqani| Department of Pathology, Collage of Medicine, Taif University, KSA, email: oamany2003@yahoo.com
Keywords
Related Articles
- EP ID EP7057
- DOI -
- Views 342
- Downloads 18
Analysis of yield and yield components in Durum wheat
To evaluate the yield and its components, 13 advanced endemic Durum wheat genotypes breededSimereh genotype by Iranian and Azerbaijan state origin, an experiment on the base of complete randomized blocks design was carri...
Effects of Management Earnings Forecast on Capital Cost and Stock Return
Forecasting earnings per share is an essential factor in investment and is considered important in share adoption methods. It is important both for providers and users. Managers try to estimate future earnings per share...
“Quran; Time culture and ethnic language reflection”
As the all-mighty Lord states in various holy verses, Quran is descended to people in Arabic. The 4th verse in Abraham Chapter says. ”No prophet is sent to any ethnical group to reveal and recite the truth, but speaking...
The Origin Of Happiness And Exhilaration In Islamic Mysticism
The mystics' approach towards the subject of happiness has been originated from Qua'nic verses and divine narrations. In religious resources, admirable happiness, noticing to the benefactor, thanking him, and God's satis...
RapidExtract, a novel biodegradable filter cartridge for capture and containment of biomolecules
DNA, RNA and protein isolation is essential in the expansion of science related to the study of these biomolecules. Extraction and purification science has since advanced so rapidly but there seems to be of the same dire...