The Ameliorating Effect of Vitamin C against Cardiopulmonary Toxicity of Zinc Oxide Nanoparticals
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2015, Vol 9, Issue 7
Abstract
It has demonstrated that nanoparticles may cause more inflammation than larger particles of the same materials at a same mass dose. The aim of this study was to investigate the ameliorating effect of vitamin C against cardiopulmonary toxicity of zinc oxide nanoparticals. Animals were divided into 4 groups, group I received vehicle orally for four weeks. Group II received vitamin C orally in a dose of (30 mg/kg) daily orally for four weeks. Group III received zinc oxide nano-particles orally in a dose 1 g/kg body weight/day for two weeks. Group IV received zinc oxide nano-particles orally in a dose 1 g/kg body weight/day for 14 days, co-administered vitamin C (30 mg/kg) daily orally, to be followed by two weeks vitamin C only (30 mg/kg) daily. Cardiac biomarkers troponin-T, lactate dehydrogenase (LDH), creatinine kinase (CK), and aspartate transaminase (AST) ) were measured. Finally, histopathological studies were performed from hear and lung sections of all rats of all groups. The results showed that administration of repeated doses of ZnO-NPs to rats significantly increased heart function biomarkers. Co-administration of vitamin C significantly reversed these changes to almost normal. Apart from these, histopathological changes also revealed the protective nature of vitamin C against ZnO-NPs induced necrotic damage of the heart and lung tissues.
Authors and Affiliations
Dalal Nemenqani| Department of Pathology, Collage of Medicine, Taif University, KSA, email: oamany2003@yahoo.com
Keywords
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- EP ID EP7057
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