The analysis of the correlations between coronary calcium score and selected cardiovascular risk factors in men
Journal Title: Polski Przegląd Kardiologiczny - Year 2010, Vol 12, Issue 3
Abstract
Introduction: Calcium Score allows for non-invasive assessment of coronary atherosclerosis and may add important information about cardiovascular risk. Calcium screening for the detection of coronary artery calcification belongs to the currently available tests. Calcium Score is independent risk factor of cardiovascular diseases. Aim of study: To determine the correlation between Calcium Score (coronary artery calcium score – CACS) and selected cardiovascular risk factors such as: plasma concentration of high density lipoprotein (HDL) and body mass index (BMI) in men without symptoms of coronary artery disease (CAD). Material and methods: The prospective study in 2007 year, included 150 patients (pts) – males, mean age 57.8±7.66 years, without symptoms of CAD. In all pts CACS was evaluated using multislice spiral computed tomography (MSCT Sensation 64 Cardiac) and Agatston scale. In all pts plasma levels of cholesterol: total, HDL and LDL (low density lipoprotein) and triglycerides, apart from plasma level of creatinine, fibrinogen, fasting glucose level and hsCRP (high sensivity C-reactive protein) were evaluated. BMI was calculated by dividing weight in kilograms by height in meters squared. Statistical analysis was performed using STATISTICA version 2006 PL. Results: Mean value of CACS was 80.35±149.61 (max CACS 845.1). Mean value of HDL was 1.25±0.28 mmol/l, total cholesterol 5.39±1.06 mmol/l, LDL 3.49±0.89 mmol/l and triglycerides 1.84±1.5 mmol/l. Mean value of creatinine was 79.85±16.5 umol/l, fasting glucose 5.48±1.45 mmol/l, fibrinogen 3.72±1.03 g/l, hsCRP 3.06±2.8, mg/l. Mean value of BMI was 28.53±4.75 kg/m2. In the statistical analysis correlations between CACS, HDL and BMI were evaluated. The statistically significant negative correlation was observed between CACS and HDL (r=-0.167; p<0.04) and similarly between BMI and HDL (r=-0.272; p<0.00076). There was statistically significant positive correlation between CACS and BMI (r=0.188; p<0.02). Conclusions: 1. In men with risk factors of atherosclerosis without CAD higher Calcium Score is observed in individuals with low concentration of HDL and with higher BMI. 2. There is a positive correlation between BMI and plasma level of HDL cholesterol in men without symptoms of CAD.
Authors and Affiliations
Katarzyna Stopyra-Pach, Mieczysław Pasowicz, Małgorzata Konieczyńska, Krystyna Duda, Marta Bazanek, Piotr Klimeczek
Keywords
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