The Antioxidant and Hepatoprotective Effect of Alcoholic Extract of Ginger Against the Cisplatininduced Oxidative Stress in Rats
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 2
Abstract
Background and Objectives: Cisplatin is an anticancer drug and highly toxic for the liver when it is used in high doses. The antioxidant stresses play a part in the toxicity of cisplatin. Considering the antioxidant properties of ginger rhizome, the present study evaluated the antioxidant effects of alcoholic extract of ginger rhizome (GREE) against the oxidative stress induced by cisplatin in rats. Materials and Methods: In this experimental study, 60 adult male rats (SD) were randomly divided into four groups including group 1 (control group), groups 2 and 4 (received 200mg/kg of GREE for 10 days), groups 3 and 4 (received 7.5 mg/kg of cisplatin intraperitoneally at the tenth day), and groups 2 and 4 (received ginger for extra three days). Finally, Tissue surfaces of malondialdehyde (MDA), reduced glutathione (GSH) and activity of superoxide dismutase enzymes, catalase, glutathione peroxidase and glutathione reductase in the liver tissue homogenates were measured. Then, these results were accorded with histopathology results. Results: In group 4, GREE decreased the amount of malondialdehyde (P<0.001) and increased the amount of liver antioxidant significantly. The histological changes were aligned with Enzymatic findings based on histopathological examinations. Conclusion: By considering antioxidant properties, GREE protects the liver of rats against the cisplatin –induced oxidative stress.The oxidative stress results from the imbalance between the released radicals in body and antioxidant defective mechanisms. In living creatures, lipid peroxidation in the walls of living cells is considered as the major target of released radicals. In these circumstances, not only the wall structure and its function are effected, but also some products of oxidation such as malondialdehyde can react with biomolecules and have cytotoxic and genotoxic effects. Thus, high amount of released radicals plays a crucial role in pathogenesis of some diseases like, diabetes, cardiovascular diseases, cancer, aging and the like [1]. Although the industrial antioxidants are widely used during recent years, most of these combinations are harmful to health [2,3]. Some evidence confirms the toxicity and malnutrition effects of industrial antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene and tert-beta-hydroxy quinone on food products. In addition, the risk of liver damage and developing cancer in laboratory animals is the major disadvantage of industrial antioxidants [3,4]. In this regard, natural antioxidants mainly found in medical plants, fruit and vegetables are very popular among the consumers, which seem to prevent some diseases [2]. Since the plants are one of the richest sources of antioxidant, more studies are getting done in this regard [2] the antioxidantrich herbs can protect cells from oxidative damages [5]. Natural antioxidants increase the plasma antioxidant potential and decrease the number of diseases like cancer, cardiovascular diseases and stroke [6]. Secondary metabolites derived from herbs such as phenol and total flavonoid are highly potential to clean the released radicals in all parts of the plant like leaves, fruits, seeds, roots and peel [7]. Thus, with regard to the high prevalence of chronic and erosive diseases, it is logical to use herbs, especially those with phenol and total flavonoid, to provide required antioxidants for body. Ginger is a potential antioxidant which decreases the released radicals (6-gingerol & shogaols) [8]. Ginger is considered as the rhizome of fresh or dried zingiber officinale and its medicinal usage dates back ancient times from the east of Asia to the tropical regions of Australia [9,10].
Authors and Affiliations
Ilyad Eissa Beagloo, Mohammad Reza Valilu, Mehrnaz Motiei, Mahdi Rahbar, Amir Hejazi
Keywords
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- EP ID EP621696
- DOI 10.26717/BJSTR.2019.19.003283
- Views 120
- Downloads 0
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