The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes
Journal Title: Jornal de Pediatria - Year 2019, Vol 95, Issue 2
Abstract
Objective The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets. Results Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p<0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p<0.05). The platelet redox status showed a negative correlation with the A1c % levels (r=−0.31; p=0.022) and the duration of type 1 diabetes (r=−0.35, p=0.012). Conclusion Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.
Authors and Affiliations
Usama Alkholy
Keywords
Related Articles
- EP ID EP497490
- DOI 10.1016/j.jped.2017.12.005
- Views 47
- Downloads 0
Socioeconomic inequality in childhood obesity and its determinants: a Blinder–Oaxaca decomposition
Objective Childhood obesity has become a priority health concern worldwide. Socioeconomic status is one of its main determinants. This study aimed to assess the socioeconomic inequality of obesity in children and adolesc...
Urotherapy in the treatment of children and adolescents with bladder and bowel dysfunction: a systematic review
Objective To identify and describe the protocols and clinical outcomes of urotherapy interventions in children and adolescents with bladder bowel dysfunction. Method Systematic review carried out in June 2018 on Medical...
Brain-focused care in the neonatal intensive care unit: the time has come
Survival rates for extremely preterm infants and for critically ill term newborns have improved steadily over the last several decades; however, these same babies continue to experience high rates of adverse neurodevelop...
Acute kidney injury in HIV-infected children: comparison of patients according to the use of highly active antiretroviral therapy
Objective To assess clinical and laboratory data, and acute kidney injury (AKI) in HIV-infected children using and not using highly active antiretroviral therapy (HAART) prior to admission. Methods A retrospective study...
A method for the assessment of facial hedonic reactions in newborns
Objective This study describes a quantitative and qualitative methodology to assess hedonic responses to sweet stimulus in healthy newborns. Methods A descriptive, cross-sectional, observational study, with healthy newb...