The antipyretic effects of Chai Ge fever relief oral liquid
Journal Title: Drug Combination Therapy - Year 2020, Vol 2, Issue 3
Abstract
Backgroud: To verify the antipyretic effect and mechanism of Chai Ge fever relief oral liquid, and to provide evidence for the clinical application of Chai Ge fever relief oral liquid. Methods: By designing three groups of experimental models of yeast-induced rat fever model, endotoxin-induced rabbit fever model, and para-influenza virus-induced rabbit fever model, the antipyretic effect and mechanism of Chai Ge fever relief oral liquid were studied by measuring body temperature before and after treatment and the expressions of protein kinase A (PKA), protein kinase C, arginine vasopressin (AVP), prostaglandin E2 and cyclic adenosine monophosphate (cAMP) in hypothalamus after administration. Results: In the yeast-induced fever model of rats, the body temperature and PKA expression levels in different dose groups of Chai Ge fever relief oral liquid were significantly different from those of the model group 1–3 h after treatment. In the rabbit fever model induced by endotoxin, different dosage groups of Chai Ge fever relief oral liquid have obvious antipyretic effect on 1–3 h after the model is established, and can significantly reduce the expression of AVP and cAMP in hypothalamus. In the para-influenza virus-induced rabbit fever model, each dose group of Chai Ge fever relief oral liquid has obvious antipyretic effect on 1–2 h after the model is established. Conclusion: Chai Ge fever relief oral liquid has good antipyretic effect on fever models induced by yeast, endotoxin and parainfluenza by regulating the expression of PKA, AVP, and cAMP.
Authors and Affiliations
Bo Wen, Cong Ma, Qin Zhang, Yang Shi, Mi-Feng Liu, Xiao-Meng Huo, Wen Gu, Pei-Pei Shao, Ping Tang
Keywords
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- EP ID EP685184
- DOI 10.12032/DCT2020A020
- Views 165
- Downloads 0
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