The combined efficacy of warming Yang therapy and Western medicine in the treatment of dilated cardiomyopathy with heart failure: A Meta-analysis
Journal Title: Drug Combination Therapy - Year 2020, Vol 2, Issue 3
Abstract
Background: To evaluate the clinical efficacy of oral administration of Chinese medicines with warming Yang effects and Western medicine in the treatment of heart failure caused by dilated cardiomyopathy. Methods: Seven databases including Chinese National Knowledge Infrastructure, Weipu database, Wanfang database, China Biomedical Literature Service System, Cochrane library, PubMed, and Embase were searched. The search date was from established to October 2019. Randomized clinical trials of dilated cardiomyopathy patients with heart failure under the combination treatment of Chinese medicines with warming Yang effects and Western medicine were included. We then assessed the methodological quality of included literatures, extracted valid data and conducted systematically evaluation according to the Cochrane systematic review method. Outcome index included clinical efficacy, left ventricular ejection fraction, and brain natriuretic peptide. Results: Meta-analysis results showed that the clinical effective rate was higher in the combination group than that in the control group (RR = 1.24, 95% CI (1.14, 1.34), P < 0.01). In addition, the combination group could improve left ventricular ejection fraction compared with the control group (Std. MD = 0.85, 95% CI (0.69, 1.01), P < 0.01). However, the meta-analysis of brain natriuretic peptide levels showed that the included literatures have higher heterogeneity and the meta-analysis results were unstable. So the results of brain natriuretic peptide were abandoned. Conclusion: Oral administration of Chinese medicines with warming Yang effects combined with Western medicine is better than Western medicine alone in improving clinical effect and left ventricular ejection fraction, but it is not clear whether brain natriuretic peptide can be improved. Because the quality of the included studies is not high and inconsistent outcome index, more standardized and rigorous randomized double-blind controlled trials are needed to validate and guide clinical use.
Authors and Affiliations
Zhe-Tao Zhang, Xiao Liu, Ze-Yuan Wei, Chao-Liang Tang
Keywords
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- EP ID EP685187
- DOI 10.12032/DCT2020B024
- Views 165
- Downloads 0
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