The analgesic, anti-inflammatory, and anti-infection effects of Chai Ge fever relief oral liquid
Journal Title: Drug Combination Therapy - Year 2020, Vol 2, Issue 2
Abstract
Backgroud: To explore the analgesic, anti-inflammatory, and anti-infective effects of Chai Ge fever relief oral liquid and provide evidence for clinical application of Chai Ge fever relief oral liquid. Methods: In this study, four groups of experiments were designed: analgesic, anti-inflammatory, antiviral, and antibacterial. In the mouse pain model, the analgesic effect of Chai Ge fever relief oral liquid was studied by the writhing method and pain threshold; the anti-inflammatory effect by measuring the level of capillary permeability in the abdominal cavity of mice in different dose groups and the weight of cotton ball granuloma formation in rats; the antiviral effect by measuring the lung index of a pneumonia model of mouse infected with influenza virus; and the antibacterial effect by comparing the difference in the death protection ratio between each dose group and the model group result. Results: In the analgesic experiment, the high and medium dose of Chai Ge fever relief oral liquid could significantly reduce the number of writhing in mice caused by acetic acid, and the pain threshold of mice in the high- and medium-dose groups was significantly increased for 1–3 hours. In the anti-inflammatory experiment, the medium-dose group could significantly inhibit the increase of capillary permeability in the abdominal cavity of mice caused by acetic acid, and the low-dose group could significantly reduce the weight of rat cotton ball granuloma. In the antiviral experiment, the high- and medium- doses of Chai Ge fever relief oral liquid could significantly reduce the lung index of normal mouse pneumonia model of influenza virus infection and achieve a higher inhibition rate. In the anti-infective experiment, the death protection rate of the high-dose group was significantly different from that of the model control group. All three dose groups could significantly prolong the survival days of infected mice. Conclusion: These experimental results prove that in addition to its antipyretic effect, Chai Ge fever relief oral liquid also has analgesic, anti-inflammatory, antiviral, and antibacterial effects.
Authors and Affiliations
Shan-Shan Guo, Ya-Xin Wang, Ying-Jie Gao, Sai-Wei Lu, Xiao-Lan Cui
Keywords
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- EP ID EP682571
- DOI 10.12032/DCT2020A015
- Views 198
- Downloads 0
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