The Antiulcer Activity of Aerial parts of Jatropa curcas.
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 4
Abstract
The anti-ulcer activity of methanolic extract of Jatropa curcas (Euphorbiaceae) aerial parts was investigated in pylorus ligation and Indomethacin induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. methanolic extract of Jatropa curcas at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions.The extract (200 mg/kg & 400 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This study indicates that Jatropa curcas aerial extract have potential anti ulcer activity in the both models. These results may further suggest that methanolic extract was found to possess additional ulcer healing properties, which might be due to its antisecretory activity.
Authors and Affiliations
Ankur Agrawal1, P. K Mohanty1*, Dr. Y. A. Jaliwala. 1, Dr. P. K. Panda2
Keywords
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