The Antiulcer Activity of Aerial parts of Jatropa curcas.
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 4
Abstract
The anti-ulcer activity of methanolic extract of Jatropa curcas (Euphorbiaceae) aerial parts was investigated in pylorus ligation and Indomethacin induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. methanolic extract of Jatropa curcas at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions.The extract (200 mg/kg & 400 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This study indicates that Jatropa curcas aerial extract have potential anti ulcer activity in the both models. These results may further suggest that methanolic extract was found to possess additional ulcer healing properties, which might be due to its antisecretory activity.
Authors and Affiliations
Ankur Agrawal1, P. K Mohanty1*, Dr. Y. A. Jaliwala. 1, Dr. P. K. Panda2
Keywords
Related Articles
- EP ID EP85802
- DOI -
- Views 137
- Downloads 0
Antifungal Activity and Phytochemical Analysis of Aqueous Extracts of Ricinus communis and Punica granatum
In the present investigation, the aqueous leaf and pericarp extracts of castor oil plant (Ricinus communis) and pomegranate (Punica granatum) were evaluated for antifungal activity against Candida species and subsequentl...
Taste masked, orally disintegrating tablet containing microspheres for immediate release
The purpose of this study was to evaluate the potential of microspheres for taste masking when incorporated intoorally disintegrating tablets. The microspheres were produced by emulsification solvent evaporation method u...
Sodium alginate: the wonder polymer for controlled drug delivery
The objective of this paper is to discuss the potential of sodium alginate as a biopolymer in the formulation development and its allied applications. There is a growing trend in pharmaceutical in food industry to avoid...
Formulation and Evaluation of Mesalamine Microspheres for Colon Targeted Drug Delivery System
Mesalamine (5-ASA) is an anti-inflammatory drug used in treatment of Crohn’sdisease and ulcerative-colitis. As Mesalamine is rapidly absorbed from the small intestine and it is necessary to develop a colon-specific deliv...
In vitro evaluation of free radical scavenging activity of medicinal plant Polyalthia longifolia (Sonner.) Thw. leaf extract
The present study was aimed at investigating the antioxidant activities of the ethanol and chloroform extracts of the leaves of Polyalthia longifolia (Sonner.) Thw. (Annonaceae). The antioxidant activities of the extrac...