The applications of gene therapy in Oral Cancer: A Review.
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 1
Abstract
In gene therapy genes or short oligonucleotide sequences are used as therapeutic molecules.it has been used to treat defective genes. DNA encoding a with therapeutic vector main machinery of gene therapy.In this therapy adverse effect of drug is decreasd. Many diseases such as ADA-SCID, X-linked SCID, Leber's congenital amaurosis (a retinal disease), Parkinson's disease, multiple myeloma, chronic and acute lymphocytic leukemia, adrenoleukodystrophy have reported of successful clinical trials. Cancer occurs due to mutations, defective gene. Surgery ,radiation and chemotherapy are the treatment modalities.gene therapy are under clinical trials for oral cancer.the aim of this article to review use of gene therapy in oral cancer.Introduction Oral cancer (OSCC, for Oral Squamous Cell Carcinoma) is a genetic disease in which the genes that control cell growth and apoptosis are mutated, allowing cells to acquire the ability to invade and metastasize. Despite research efforts and new therapies, five-year survival has not improved over the past 4-5 decades. Patients with recurrent oral cancer that is refractory to chemotherapy or radiotherapy have a life expectancy of only months and the response rate to second- and third-line treatments is only 15% .1. The patients with cancer usually remain resistant to the standard therapies which are used readily. But, there may be chances of acute and chronic toxicities, as well as secondary malignancies. Hence, to improve the treatment modality and the over- all survival rates, gene therapy has emerged in the field of bio-medicine, which replaces the defective gene and this is repaired by a therapeutic gene.
Authors and Affiliations
Sruthy Davis
Keywords
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