THE ASSOCIATION BETWEEN ADIPONECTIN, LEPTIN, PROINFLAMMATORY MARKERS AND METABOLIC SYNDROME IN OBESE, NONDIABETIC SUBJECTS
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 2
Abstract
The aim of this study was to evaluate the association between adipokines (adiponectin and leptin), inflammatory markers, insulin resistance and metabolic syndrome in obese, non-diabetic subjects. Methods: Thirty three obese patients (19 men and 14 women) with metabolic syndrome (MetS) defined according IDF criteria, twenty three obese patients (12 men and 11 women) without MetS and eighteen controls (9 men and 9 women) lean subjects without MetS were included. In all individuals were assessed MetS components as well as serum levels of adiponectin, leptin, high sensitive C-reactive protein (hs-CRP), insulin, fibrinogen and leukocyte count (WBC). Results: In both sexes, obese subjects with MetS, compared to obese subjects without MetS had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), HOMA-IR, WBC, plasma concentrations of hs-CRP, leptin, triglyceride and fibrinogen and significantly lower concentration of HDL-cholesterol. A significantly lower concentration of adiponectin and a higher concentration of fasting insulin were observed in obese men with MetS compared to obese men without MetS. In all study subjects adiponectin was negatively correlated with BMI, body fat, triglyceride, HOMA-IR and positively correlated with HDL-cholesterol and hs-CRP was positively correlated with BMI, waist, body fat, triglyceride, HOMA-IR and negatively correlated with HDL-cholesterol. Hs-CRP was positively correlated with leptin in obese women and negatively correlated with adiponectin in obese men. Conclusions: In obese, non-diabetic subjects adiponectin, leptin, proinflammatory state and prothrombotic state are strongly correlated with MetS. Obese subjects with MetS had higher levels of hs-CRP and lower levels of adiponectin. These findings are important in clinical practice because permit an earlier identification of high risk subjects.
Authors and Affiliations
R. Vasilescu, S. Ifrim, C. Ionescu-Tirgoviste, A. Muresan
Keywords
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