The Auxiliary Role of Hematological Parameters in Diagnosing Localized Germ Cell Testicular Tumor
Journal Title: The Bulletin of Urooncology - Year 2020, Vol 19, Issue 4
Abstract
Objective: There is a lack of information about the relationship between germ cell testicular tumors and hematological parameters commonly used in other tumors. In this study, it was aimed to determine the value of hematological parameters used in other malignancies in the diagnosis of localized germ cell testicular cancer. Materials and Methods: Hematological parameters between patients who underwent radical orchiectomy with a pre-diagnosis of localized germ cell testicular tumor and those who underwent varicocelectomy in the same period as the control group between January 2015 and March 2019 in our clinic were compared to determine the diagnostic value of hematological parameters in testicular tumor. Results: The mean age of 39 patients diagnosed as having localized testicular tumor was 33 years. While seminoma was detected in 17 patients, non-seminomatous germ cell tumors were detected in 22 patients. In the assessment of preoperative blood samples; neutrophil count (5.6 vs 4.1, p≤0.001), neutrophil percentage (65.8 vs 57.4, p≤0.001) and neutrophil/lymphocyte ratio (2.6 vs 1.8, p≤0.001) were significantly higher, while lymphocyte ratio was significantly lower (25.3 vs 31.4, p≤0.001) in patients with testicular tumor than in the control group (n=121). In the receiver operating characteristic analysis performed for the neutrophil/ lymphocyte ratio, the cut-off point was found to be 2.25 (area under the curve =0.71, 95% confidence interval: 0.622-0.816, sensitivity: 66.7%, selectivity: 73.6%). Conclusion: Neutrophil/lymphocyte ratio, which is one of the hematological parameters, can be used as an auxiliary tool for examination and imaging methods in the diagnosis of stage I germ cell testicular tumor, which is considered to be an early stage.
Authors and Affiliations
İbrahim Kartal, Sertaç Çimen, Görkem Özenç, Alihan Kokurcan, Burhan Baylan, Nihat Karakoyunlu, Orhan Yiğitbaşı, Fatih Yalçınkaya
Keywords
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- EP ID EP691642
- DOI 10.4274/uob.galenos.2019.1430
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