The biochemical assessment of coronary artery disease in patients of mental depression
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Problem Statement: Mental depression as such though a social problem but its complications share a good number of morbidity and mortality. Various reports have suggested that mental depression can lead to coronary artery disease and obesity which are independently morbidity factors. These mental depressive patients are presenting with multifaceted problems and complications- including diabetes mellitus, ypertension, atherosclerotic cardiovascular, dyslipidemia, obesity, etc. Methods: The cases and controls both were selected by simple random sampling method done in one year from March 2016 to January 2017. The patients are categorized as per ‘Center of Epidemiologic Study of Depression’ scaling according to their depressive severity. The patients selected from the psychiatric OPD, and the biochemical investigation was done in Dept of Biochemistry M.G.M. Medical College and L.S.K. Hospital. Kishanganj, Bihar. Total 50 patients were taken between the age group of 15 to 50 years. 50 patients of same age group taken as control irrespective whether suffering from CAD, dyslipidemia, obesity but without clinical evidence of mental depression. Results: Compared the control with the CES-D A, B, C and D group. We found that HOMA- IR significantly raised in D group over control, A, B, C group.TG level was significantly raised in D group compared to control, A and B group. In C group the rise of TG level is not significant but has raised to 120% over the Group D. Cholesterol level is significantly raised (p value <0.05) in group D over control and group A, B, C. The HDL value is significantly lowered in group B compared to control, A, B, and C values but group C has shown decrease in HDL value of about 38.6%(mean) over group B value. Group B also shows 79.17% lower than that of group A. It denotes that mental depression has such caused the lowering of HDL and increase of atherogenesis stage by stage in a matched age group patients irrespective of the antipsychiatric treatment they have received.
Authors and Affiliations
Kavita Jaiswal, Debjit Mitra
Keywords
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