The Clinical Feature of Chronic Hepatitis B Patients with High HBV pgRNA
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1
Abstract
ackground and Aims At present, nucleos(t)ide analogue (NA) is usually used to treat chronic hepatitis B, but there are still some patients with high levels of pgRNA after long-term treatment. We tried to study the clinical characteristics of this part of the population. Methods A total of 211 patients who had been treated with NAs for more than one year and had been followed up in our outpatient department for a long time were included in the study. The concentrations of HBV serological (HBsAg, HBeAg, HBV DNA, anti-HBe) /biochemical indicators (ALT, AST, GGT, AFP) were measured in this study. Results ALT/AST/HBV DNA/HBsAg in high pgRNA group was significantly higher than those in low pgRNA group, and the HBeAg negative rate of high pgRNA group was much lower than that of low pgRNA group. Conclusion CHB patients with high pgRNA are more likely to have relatively active viruses and more severe liver inflammation. In addition, in terms of virological response, the proportion of HBeAg negative in high pgRNA population is significantly higher than that in low pgRNA population, and the titer of HBsAg is significantly higher than that of people with low pgRNA.
Authors and Affiliations
Yunzhe Zhang, Xuezhong Lei
Keywords
Related Articles
- EP ID EP740139
- DOI 10.54457/DR.202301001
- Views 30
- Downloads 0
Clinical Applications of Recombinant Human Granulocyte Colony-Stimulating Factor in Reproductive Medicine: Expert Consensus
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is primarily indicated for neutropenia caused by various etiologies in clinical practice. Recently, it has been shown to have some therapeutic effects and...
Hepatic Paragonimiasis: A Case Report and Literature Review
Paragonimiasis is a parasitic disease caused by paragnonimus, which primarily caused infection in the lung, and ectopic infection was less common. Ectopic paragonimiasis are more likely to be misdiagnosed as malignancy o...
Multiparameter Flow Cytometry: An Important Auxiliary Tool for The Diagnosis and Differential Diagnosis of Myelodysplastic Neoplasms
Multiparameter flow cytometry (MFC) shows promise in the diagnosis and differential diagnosis of myelodysplastic neoplasms (MDS). By identifying abnormal immunophenotypes of different cell lineages in bone marrow (BM) ce...
HBeAg Negativity is Associated with a Higher Risk of Liver-Related Death in Patients with Chronic Hepatitis B Related Liver Cirrhosis
Background and aims Few studies reported the association between the survival of patients with chronic hepatitis B (CHB)-related liver cirrhosis (LC) and hepatitis B e antigen (HBeAg) state. Methods Three hundred and ni...
Recurrent Middle Ear Cancer: Case Report
Background: Middle ear cancer is clinically uncommon, representing approximately 1.5% of ear malignancies and 0.03% to 0.06% of all cancers. Recurrent cases of middle ear cancer are particularly rare. This report discuss...