The Clinical Feature of Chronic Hepatitis B Patients with High HBV pgRNA
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1
Abstract
ackground and Aims At present, nucleos(t)ide analogue (NA) is usually used to treat chronic hepatitis B, but there are still some patients with high levels of pgRNA after long-term treatment. We tried to study the clinical characteristics of this part of the population. Methods A total of 211 patients who had been treated with NAs for more than one year and had been followed up in our outpatient department for a long time were included in the study. The concentrations of HBV serological (HBsAg, HBeAg, HBV DNA, anti-HBe) /biochemical indicators (ALT, AST, GGT, AFP) were measured in this study. Results ALT/AST/HBV DNA/HBsAg in high pgRNA group was significantly higher than those in low pgRNA group, and the HBeAg negative rate of high pgRNA group was much lower than that of low pgRNA group. Conclusion CHB patients with high pgRNA are more likely to have relatively active viruses and more severe liver inflammation. In addition, in terms of virological response, the proportion of HBeAg negative in high pgRNA population is significantly higher than that in low pgRNA population, and the titer of HBsAg is significantly higher than that of people with low pgRNA.
Authors and Affiliations
Yunzhe Zhang, Xuezhong Lei
Keywords
Related Articles
- EP ID EP740139
- DOI 10.54457/DR.202301001
- Views 35
- Downloads 0
Is Preoperative Radiotherapy Necessary for Resectable Locally Advanced Squamous Cell Esophageal Carcinoma?
Based on the guidelines for esophageal and esophagogastric junction cancers, the standard of care for resectable locally advanced (cT2, N0 [high-risk lesions: lymphovascular invasion, ≥3 cm, poorly differentiated]; cT1b-...
Incidence of Side Effects During Tenofovir Alafenamide Monotherapy in Patients with Chronic Hepatitis B
Objective Tenofovir alafenamide (TAF) is a new prodrug of tenofovir that is widely used in chronic hepatitis B (CHB) patients, and its side effects have rarely been reported. We aimed to evaluate the incidence of side ef...
Anti-Cancer Agents Work in Antagonism with Inhibitors of HSP 72
Purpose The heat shock genes are evidenced to be active in the migration and are major promoters of several human malignancies. The inclined expression of HSP 72 proteins play an inevitable role in protecting cancer cell...
Primary Extramedullary Plasmacytoma of the Kidney: A Case Report and Literature Review
Extramedullary plasmacytomas (EMPs) usually occur in the upper respiratory tract, the occurrence in the kidney is extremely rare. The present study reported a case of primary renal plasmacytoma in a 46-year-old male pati...
Recurrent Middle Ear Cancer: Case Report
Background: Middle ear cancer is clinically uncommon, representing approximately 1.5% of ear malignancies and 0.03% to 0.06% of all cancers. Recurrent cases of middle ear cancer are particularly rare. This report discuss...