The Clinical Outcome among the Patients of Guillain Barre Syndrome After Therapeutic Plasma Exchange: Critical Reassessment of Effectiveness at BSMMU
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Introduction: Guillain–Barré syndrome (GBS) is an acute monophasic paralyzing illness usually provoked by a preceding infection. Mainly intravenous immunoglobulin (IVIG) and plasmapheresis (PP)/plasma exchange (PE) are used to treat this disease where for developing country IVIG is not cost effective and suitable. Objective: In this study our main goal is to evaluate the clinical Outcome among the Patients of Guillain Barre Syndrome after therapeutic plasma exchange. Method: This open label randomized clinical control trial was carried out at Department of Transfusion Medicine of BSMMU, Dhaka from April 2017-December 2017.The patients who are candidate for IVIg will be enrolled. One group received TPE and other will be treated in the conventional manner and conducted as control.40 patients with the age range of 15 to 60 years admitted to Intensive care unit of BSMMU and referred to neurology Department of this hospital for performing TPE. All patients had clinical findings of Guillain-Barre syndrome (GBS) and/or GBS variants. Results: During study it was observed that 4(20.0%) patients belonged to age 25-34 years, 35-44 years and 45-54 years respectively in TPE group and 35-44 years and 45-54 years respectively in IvIg group and direct costs of IVIg therapy are more than twice that of TPE. Also patient's condition started improving after three cycles of TPE with power in the upper limbs 4/5 and lower limbs 3/5. Conclusion: It can be concluded that TPE appears to be a less expensive and most effective first-line therapy option for treatment of patients with GBS.
Authors and Affiliations
Sheikh Anisul Haque, Fahmida Kabir, Sanjeela Nahreen Chowdhury, MdSaif Bin Mizan, Sumaya Afroze
Keywords
Related Articles
- EP ID EP537034
- DOI 10.21276/ijmrp.2018.4.5.045
- Views 98
- Downloads 0
Evaluation of Biochemical, Haematological Parameters and Noninvasive Prognostic Scores in Alcoholic Liver Disease with and without Complications
Background: Chronic and excessive alcohol ingestion is one of the major causes of liver disease in the industrialized nations. The spectrum of pathology of alcoholic liver injury ranges from fatty liver to alcoholic hepa...
Assessment of Antenatal Umbilical Coiling Index in Second Trimester as a Prognostic Marker of Perinatal Outcome
Objectives: To evaluate the antenatal umbilical cord coiling index obtained during fetal anatomic survey in the second trimester as a predictor of adverse pregnancy outcome. Methodology: A total of 100 pregnant women in...
Clinical, Radiologic and Histomorphologic Analysis of Ameloblastoma and It's Variants
Introduction: Ameloblastoma, the rare benign neoplasm of jaw, arises from the odontogenic epithelium. These are slowly progressive, locally aggressive tumours with high recurrence rate. Clinical behaviour of these tumour...
Antibiotic Susceptibility Pattern of Bacteria Causing Lower Respiratory Tract Infections in HIV/AIDS Patients with Correlation to CD4+T Cell Counts
Introduction: One of the commonest infectious diseases of humans is lower respiratory tract infection (LRTI). Opportunistic pulmonary disease remains an important cause of acute illness and death in patients with advance...
Study of Nasal Mucosal Flora in Acute and Chronic Sinusitis
Introduction: Microbiological investigation and selection of antimicrobial agents are important for infection control and to avoid complications. It is also suggested to have continuous medical education for effective an...