The clinical significance of fatty acid binding proteins
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Excessive levels of free fatty acids are toxic to cells. The human body has evolved a defense mechanism in the form of small cytoplasmic proteins called fatty acid binding proteins (FABPs) that bind long-chain fatty acids (LCFA), and then refer them to appropriate intracellular disposal sites (oxidation in mitochondria and peroxisomes or storage in the endoplasmic reticulum). So far, nine types of these proteins have been described, and their name refers to the place in which they were first identified or where they can be found in the greatest concentration. The most important FABPs were isolated from the liver (L-FABP), heart (H-FABP), intestine (I-FABP), brain (B-FABP), epidermis (E-FABP) and adipocytes (A-FABP). Determination of H-FABP is used in the diagnosis of myocardial infarction, and L-FABP in kidney lesions of different etiologies. It is postulated that FABPs play an important role in the pathogenesis of metabolic diseases. Elevated levels of A-FABP have been found in the pericardial fat tissue and were associated with cardiac dysfunction in obese people. A rise in A-FABP has been observed in patients with type II diabetes. I-FABP is known as a marker of cell damage in the small intestine. Increased concentration of B-FABP has been associated with human brain tumors such as glioblastoma and astrocytoma, as well as with neurodegenerative diseases (Alzheimer’s, Parkinson’s) and other disorders of cognitive function. The aim of this work was to present current data on the clinical significance of fatty acid binding proteins.
Authors and Affiliations
Barbara Choromańska, Piotr Myśliwiec, Jacek Dadan, Hady Hady, Adrian Chabowski
Keywords
Related Articles
- EP ID EP66572
- DOI -
- Views 150
- Downloads 0
Staphylococcus aureus biofilm and the role of bacteriophages in its eradication
The ability to form biofilm is an important virulence factor of many microorganisms. Infections involving biofilms account for approx. 65% of all human infections. Biofilms may develop on intravascular catheters or impla...
Wpływ chemioterapii na stężenie adypokin we krwi u pacjentów z rakiem jelita grubego
The correlations between aging of the human body, oxidative stress and reduced efficiency of repair systems
The article presents an current knowledge overview about the importance of oxidative stress and reduced efficiency of repair processes during the aging process of the human body. Oxidative damage to cellular macromolecul...
Akumulacja lipidów (triacylo-, diacylogliceroli i ceramidów) wewnątrz hepatocytów, a rozwój insulinooporności wątrobowej
Insulinoopornością określa się zmniejszenie wrażliwości tkanek na insulinę. Najczęściej jest ona związana z defektem receptora insulinowego i/lub kaskady kinaz insulinowego przekaźnictwa wewnątrzkomórkowego. Insulinoop...
Molecular recognition of viral infections – immune response stimulation
The mammalian immune system has evolved several mechanisms that allow bacterial and viral infections to be successfully fought. Animal cells are able to recognize viral infection and this recognition is dependent on th...